PMID: 9661287Jul 14, 1998Paper

Targeting of tetrathiomolybdate on the copper accumulating in the liver of LEC rats

Journal of Inorganic Biochemistry
Y Ogra, K T Suzuki

Abstract

The uptake of tetrathiomolybdate (TTM) by the liver and the removal of copper (Cu) accumulating in the liver in a form bound to metallothionein (MT) by TTM were studied in Long-Evans cinnamon (LEC) rats, an animal model of Wilson disease, in order to develop better treatments for the disease and Cu toxicity. Although molybdenum (Mo) was incorporated in a dose-dependent manner into the livers of both LEC and Long-Evans agouti (LEA) rats, the original strain of LEC rats used as a reference animal, the uptake into the liver of LEC rats was 13 times higher than that in LEA rats. The concentration of Mo in the soluble fraction plateaued and it was distributed more in the insoluble fraction with a higher dose in LEC rats. The concentration of Cu in the whole livers of LEC rats was decreased by TTM in a dose-dependent manner only at lower doses. However, the concentration of Cu in the soluble fraction continued to decrease with the dose of TTM. The results can be explained in terms of complex formation. Namely, TTM forms a complex with Cu, tentatively referred to a Cu/TTM complex, that can be effluxed into the bloodstream, and then binds selectively to albumin when the dose of TTM is low. On the other hand, TTM forms an insoluble comp...Continue Reading

References

May 15, 1992·Biochemical and Biophysical Research Communications·H SakuraiK Kawano
Jan 1, 1991·Archives of Neurology·G J BrewerK J Kluin
Jul 1, 1990·Journal of Gastroenterology and Hepatology·K Gibbs, J M Walshe
Oct 1, 1990·Journal of Comparative Pathology·J M Howell, J S Kumaratilake
Jan 1, 1989·Journal of Inorganic Biochemistry·S R GooneratneJ S Kumaratilake
Jul 11, 1987·Lancet·I H ScheinbergR J Stockert
Jan 1, 1980·Journal of Inorganic Biochemistry·N J Clarke, S H Laurie
Apr 1, 1981·Journal of Inorganic Biochemistry·C F MIllsG Weham
Mar 1, 1995·Journal of Hepatology·G FaaG Crisponi
May 15, 1994·Journal of Inorganic Biochemistry·K T SuzukiY Aoki
Jul 1, 1994·The Biochemical Journal·Y YamaguchiJ D Gitlin
Nov 30, 1993·Biochemical and Biophysical Research Communications·Y YamaguchiJ D Gitlin
Dec 30, 1993·Biochemical and Biophysical Research Communications·S Hiyamuta, N Takeichi
Apr 1, 1993·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·G Mulryan, J Mason
May 1, 1993·Gastroenterology·L S Friedman, J C Yarze
Oct 1, 1995·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·K T SuzukiM Ohmichi
Apr 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K SoneM Nagao
Apr 1, 1959·The Journal of Pathology and Bacteriology·J S HOWELL

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Citations

Feb 3, 2007·Brain Research Reviews·Paolo Zatta, Adrian Frank
Mar 23, 2000·Chemico-biological Interactions·Y KomatsuK T Suzuki
Apr 20, 2010·Chemico-biological Interactions·Susana Rivera-MancíaSergio Montes
Feb 22, 2012·Journal of Hepatology·UNKNOWN European Association for Study of Liver
Apr 25, 2015·American Journal of Veterinary Research·Christina M ChanWilliam D Schall
May 3, 2016·International Journal of Molecular Sciences·Eiichi Tokuda, Yoshiaki Furukawa
May 29, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Eve A RobertsUNKNOWN American Association for Study of Liver Diseases (AASLD)

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