Targeting Oxidative Stress for Disease Prevention and Therapy: Where Do We Stand, and Where Do We Go from Here.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Cristina VassalleLaura Sabatino

Abstract

Oxidative stress (OxS) is one of the main processes related to aging and a common denominator of many different chronic/degenerative diseases (e.g., cardiovascular and neurodegenerative conditions and cancer). Thus, its potential modulation by supplementation/pharmacological therapy caused a lot of interest. However, these expectations have been mitigated by the obtainment of controversial results (beneficial, null, or adverse effects) following antioxidant interventions. Here, we discuss the current understanding of OxS assessment in health and disease, challenges and the potential of its evaluation in clinical practice, and available and future development for supplementation and pharmacologic strategies targeting OxS.

References

Apr 1, 1997·Seminars in Cancer Biology·S T Whiteside, A Israël
Sep 3, 2002·Atherosclerosis·Leonard Kritharides, Roland Stocker
Jun 5, 2003·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Mark D EngelmannI Francis Cheng
Dec 23, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ntei AbuduStanley S Levinson
Dec 1, 2004·Annual Review of Genetics·Deborah E Barnes, Tomas Lindahl
Jan 3, 2006·Annals of the New York Academy of Sciences·Richard G Cutler
Jan 3, 2006·Annals of the New York Academy of Sciences·Richard G CutlerChristopher Heward
Nov 8, 2006·Clinical Chemistry and Laboratory Medicine : CCLM·Cristina VassalleGian Carlo Zucchelli
Aug 5, 2008·Trends in Molecular Medicine·Ingo BüssingHelge Grosshans
Dec 2, 2008·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Niki Katsiki, Christos Manes
Sep 15, 2010·Free Radical Research·Corinne M SpickettNeven Zarkovic
Apr 15, 2011·Gene Therapy·D Peer, J Lieberman
Jun 28, 2011·The New England Journal of Medicine·Pablo E PergolaUNKNOWN BEAM Study Investigators
Oct 13, 2011·JAMA : the Journal of the American Medical Association·Eric A KleinLaurence H Baker
Jan 31, 2012·Chemistry & Biology·John C Burnett, John J Rossi
Feb 4, 2012·Circulation Research·Eva van RooijArthur A Levin
Jul 12, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lisa D MooreGuoping Fan
Jul 13, 2012·Nutrition·Vanessa Fuchs-Tarlovsky
Jul 20, 2012·Nature Reviews. Cancer·Michael B Sporn, Karen T Liby
Nov 28, 2012·Journal of Vascular Surgery·Luis Condezo-HoyosM Carmen González
Jan 9, 2013·Annual Review of Pharmacology and Toxicology·Qiang Ma
Feb 19, 2013·Biochemical Pharmacology·Chengyue ZhangAh-Ng Tony Kong
Apr 9, 2013·Bioorganic & Medicinal Chemistry Letters·Longqin HuBenito Munoz
Dec 4, 2013·Anti-cancer Agents in Medicinal Chemistry·Natalia G VallianouChristos Kazazis
Aug 12, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·D Haussecker
Oct 28, 2014·Current Drug Targets·Albino CarrizzoCarmine Vecchione
Dec 3, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Elango BhakkiyalakshmiKunka Mohanram Ramkumar
Jan 27, 2015·Cellular and Molecular Neurobiology·Michelli Erica Souza FerreiraSandro Percário
Jun 4, 2015·European Journal of Clinical Nutrition·A A F CariocaN R T Damasceno
Jun 11, 2015·Nutrition·Alessandro PingitoreCristina Vassalle
Dec 15, 2015·Frontiers in Cardiovascular Medicine·Katarzyna GoszczIan L Megson
Jan 20, 2016·Antioxidants·Kyriazoula ChatzianagnostouCristina Vassalle
Jun 11, 2016·Current Pharmacology Reports·Jun He, Bing-Hua Jiang
Jul 21, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Constance A SobseyChristoph H Borchers
Sep 20, 2016·Physiological Research·M BarančíkI Dovinová

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Citations

Sep 16, 2020·Antioxidants·Helmut Sies
Mar 7, 2021·Antioxidants·Anna Maria Fratta Pasini, Luciano Cominacini
Jun 14, 2021·Environmental Research·Chi-Hsin S ChenChang-Chuan Chan
Jul 15, 2021·Oxidative Medicine and Cellular Longevity·Yunguang WangJuan Jin

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Methods Mentioned

BETA
MDA
enzyme-linked immunosorbent
ELISA
ubiquitination
biopsies
pharmacotherapy

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