Targeting oxidative stress in embryonal rhabdomyosarcoma

Cancer Cell
Xiang ChenSt. Jude Children’s Research Hospital–Washington University Pediatric Cancer Genome Project

Abstract

Rhabdomyosarcoma is a soft-tissue sarcoma with molecular and cellular features of developing skeletal muscle. Rhabdomyosarcoma has two major histologic subtypes, embryonal and alveolar, each with distinct clinical, molecular, and genetic features. Genomic analysis shows that embryonal tumors have more structural and copy number variations than alveolar tumors. Mutations in the RAS/NF1 pathway are significantly associated with intermediate- and high-risk embryonal rhabdomyosarcomas (ERMS). In contrast, alveolar rhabdomyosarcomas (ARMS) have fewer genetic lesions overall and no known recurrently mutated cancer consensus genes. To identify therapeutics for ERMS, we developed and characterized orthotopic xenografts of tumors that were sequenced in our study. High-throughput screening of primary cultures derived from those xenografts identified oxidative stress as a pathway of therapeutic relevance for ERMS.

References

Oct 1, 1976·Science·P C Nowell
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·H ScrableC Sapienza
May 7, 1998·The International Journal of Biochemistry & Cell Biology·F G Barr
Aug 22, 2002·Proceedings of the National Academy of Sciences of the United States of America·Lisa M ButlerVictoria M Richon
May 2, 2006·Statistical Applications in Genetics and Molecular Biology·Bin Zhang, Steve Horvath
Mar 23, 2007·Proceedings of the National Academy of Sciences of the United States of America·Marco GymnopoulosPeter K Vogt
Jul 25, 2009·Nature Reviews. Cancer·Erwin F Wagner, Angel R Nebreda
Aug 15, 2009·Genes, Chromosomes & Cancer·Simone MartinelliCarlo Dominici
Feb 6, 2010·Nature Medicine·Simone Hettmer, Amy J Wagers
Mar 31, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel WilliamsonOlivier Delattre
Jul 23, 2011·Genes & Cancer·Stephan GysinFrank McCormick
Dec 7, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Neerav ShuklaMarc Ladanyi
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Ying HuKent W Hunter
Aug 25, 2012·Nature Reviews. Cancer·Karen Block, Yves Gorin

❮ Previous
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Citations

Dec 2, 2014·Pediatric Clinics of North America·Josephine H HaDuongLeo Mascarenhas
Jul 26, 2015·Cell Cycle·Eugenio Monti, Alessandro Fanzani
Sep 24, 2015·Seminars in Cell & Developmental Biology·Marco Wachtel, Beat W Schäfer
Sep 29, 2015·Chinese Journal of Cancer·Jia-Li HuSong Gao
Oct 1, 2015·Sarcoma·Xin SunZhenfeng Duan
Jun 9, 2015·Biochimica Et Biophysica Acta·Abdalla D MohamedHenning Wackerhage
Aug 1, 2015·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Wenyue SunFrederic G Barr
Jun 25, 2015·Nature Reviews. Cancer·Venkatesh P KashiRene L Galindo
Apr 12, 2015·Developmental Biology·Elizabeth StewartMichael A Dyer
Mar 10, 2015·The Journal of Clinical Investigation·Joachim AlbersIan J Frew
Apr 8, 2014·Cell Reports·Xiang ChenUNKNOWN St. Jude Children’s Research Hospital–Washington University Pediatric Cancer Genome Project
May 17, 2014·The International Journal of Biochemistry & Cell Biology·Maciej CieślaAlicja Józkowicz
Dec 18, 2013·Cancer Cell·Minsi ZhangDavid G Kirsch
Mar 7, 2015·Nature Communications·Emilia M PintoGerard P Zambetti
Mar 12, 2015·Frontiers in Oncology·Simone HettmerAmy J Wagers
Mar 15, 2015·PLoS Genetics·Li ChenJaved Khan
Oct 18, 2016·Pediatric Blood & Cancer·Rajen J ModyArul M Chinnaiyan
Apr 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Eleanor Y ChenDavid M Langenau
Oct 27, 2015·PloS One·Katherine K SlemmonsCorinne M Linardic
Jan 13, 2017·ELife·Inês M TenenteDavid M Langenau
Jan 31, 2017·Nature Medicine·Nathan C SheffieldEleni M Tomazou
Jan 22, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gregory A MastersJyoti D Patel
Jun 10, 2017·Pediatric Blood & Cancer·Simone HettmerMelanie Boerries
Mar 1, 2018·Nature·Susanne N GröbnerStefan M Pfister
Aug 8, 2017·International Journal of Molecular Sciences·Alessandro Fanzani, Maura Poli

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