Targeting oxidative stress to reduce osteoarthritis

Arthritis Research & Therapy
Blandine Poulet, Frank Beier

Abstract

Osteoarthritis (OA) is the commonest chronic disease, with an estimated 9.6 % of men and 18.0 % of women aged over 60 years having symptomatic OA according to the World Health Organisation. Despite this prevalence, no therapies to slow disease progression are currently available. Oxidative stress has been described as an important factor in various diseases, and more recently in OA. Evidence for using antioxidants to reduce OA severity is slowly accumulating but further understanding of their chondroprotective mechanisms in joint tissues is still required to demonstrate potential benefit to patients. A new study implicates the transcriptional repressor Bach-1 and its downstream target HO-1 as important players in this process.

References

Mar 22, 2014·Annals of the Rheumatic Diseases·Yue ZhangMohit Kapoor
Sep 27, 2015·Arthritis Research & Therapy·Dawei CaiWangsen Cao
Oct 16, 2015·Arthritis Research & Therapy·Tsuyoshi TakadaMitsuo Ochi

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Citations

Apr 7, 2017·Nature Reviews. Rheumatology·Ali MobasheriUrsula Fearon
Sep 13, 2019·Arthritis Research & Therapy·Louise H W KungRaymond P Boot-Handford
Jan 4, 2019·Tissue Engineering and Regenerative Medicine·Jaeseong ParkTong In Oh
May 28, 2017·Molecular Neurobiology·Diana Sofia Marques NascimentoFani Lourença Moreira Neto
Jan 3, 2019·Inflammopharmacology·Kizhakkeppurath Kumaran AjeeshkumarGopinathan Pillai Sreekanth
Jul 2, 2020·Scientific Reports·Mandy J PeffersTim J M Welting
May 29, 2018·Matrix Biology : Journal of the International Society for Matrix Biology·Yamini Krishnan, Alan J Grodzinsky
Mar 16, 2021·Journal of Clinical Orthopaedics and Trauma·Thiago SettiJosé Fábio Santos Duarte Lana
Apr 13, 2021·Biochemical Society Transactions·David J Wilkinson
Apr 20, 2021·Journal of Proteome Research·Maxime R Eveque-MourrouxBerta Cillero-Pastor
Apr 21, 2018·International Journal of Biological Macromolecules·Chao ZhuangNanwei Xu

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