Targeting peptide-decorated biomimetic lipoproteins improve deep penetration and cancer cells accessibility in solid tumor

Acta Pharmaceutica Sinica. B
Tao TanSiling Wang

Abstract

The limited penetration of nanoparticles and their poor accessibility to cancer cell fractions in tumor remain essential challenges for effective anticancer therapy. Herein, we designed a targeting peptide-decorated biomimetic lipoprotein (termed as BL-RD) to enable their deep penetration and efficient accessibility to cancer cell fractions in a tumor, thereby improving the combinational chemo-photodynamic therapy of triple negative breast cancer. BL-RD was composed of phospholipids, apolipoprotein A1 mimetic peptide (PK22), targeting peptide-conjugated cytotoxic mertansine (RM) and photodynamic agents of DiIC18(5) (DiD). The counterpart biomimetic lipoprotein system without RM (termed as BL-D) was fabricated as control. Both BL-D and BL-RD were nanometer-sized particles with a mean diameter of less than 30 nm and could be efficiently internalized by cancer cells. After intravenous injection, they can be specifically accumulated at tumor sites. When comparing to the counterpart BL-D, BL-RD displayed superior capability to permeate across the tumor mass, extravasate from tumor vasculature to distant regions and efficiently access the cancer cell fractions in a solid tumor, thus producing noticeable depression of the tumor growth...Continue Reading

Citations

May 1, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zheng Lian, Tianjiao Ji
Mar 3, 2021·ACS Biomaterials Science & Engineering·Junli ZhangZhenzhong Zhang
Mar 30, 2021·Journal of Drug Targeting·Selin Seda Timur, R Neslihan Gürsoy
May 5, 2021·Expert Opinion on Drug Delivery·Miguel Pereira-SilvaAna Cláudia Paiva-Santos
Aug 19, 2020·ACS Applied Materials & Interfaces·Zipeng ZhangNa Zhang
Oct 28, 2021·Advanced Healthcare Materials·Xiaoxuan XuZhiwen Zhang

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BETA
biopsy
electron microscopy
nuclear magnetic resonance
by dynamic light

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Enspire
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