Targeting PI3K/Akt/mTOR signaling pathway by polyphenols: Implication for cancer therapy

Life Sciences
Mohammad Mirza-Aghazadeh-AttariMaryam Majidinia

Abstract

Cancer is one of the biggest challenges facing medicine and its cure is regarded to be the Holy Grail of medicine. Therapy in cancer is consisted as various artificial cytotoxic agents and radiotherapy, and recently immunotherapy. Recently much attention has been directed to the use of natural occurring agents in cancer therapy. One of the main group of agents utilized in this regard is polyphenols which are found abundantly in berries, fruits and vegetables. Polyphenols show to exert direct and indirect effects in progression of cancer, angiogenesis, proliferation and enhancing resistance to treatment. One of the cellular pathways commonly affected by polyphenols is PI3K/Akt/mTOR pathway, which has far ranging effects on multiple key aspects of cellular growth, metabolism and death. In this review article, evidence regarding the biology of polyphenols in cancer via PI3K/Akt/mTOR pathway is discussed and their application on cancer pathophysiology in various types of human malignancies is shown.

Citations

Apr 25, 2020·IUBMB Life·Mohammad Mirza-Aghazadeh-AttariBahman Yousefi
Aug 9, 2020·OncoTargets and Therapy·Wei HanWei Guan
Aug 31, 2020·Immunology and Cell Biology·Shahin HallajFarhad Jadidi-Niaragh
Dec 20, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Bin XuJunfei Shao
Feb 7, 2021·Chemico-biological Interactions·Ainaz MihanfarMaryam Majidinia
Mar 5, 2021·Frontiers in Oncology·Arthur-Quan TranVictoria Bae-Jump
Oct 10, 2020·Seminars in Diagnostic Pathology·Deyin Xing, Oluwole Fadare
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Jul 11, 2021·Life Sciences·Shahin HallajFarhad Jadidi-Niaragh
Jul 10, 2021·Cancer Investigation·Dongning LiXiaoyan Zhao
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gregoria GregoriouAndreas I Constantinou
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Sep 12, 2020·Recent Patents on Anti-cancer Drug Discovery·Arunaksharan Narayanankutty

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