Abstract
Cancer is one of the biggest challenges facing medicine and its cure is regarded to be the Holy Grail of medicine. Therapy in cancer is consisted as various artificial cytotoxic agents and radiotherapy, and recently immunotherapy. Recently much attention has been directed to the use of natural occurring agents in cancer therapy. One of the main group of agents utilized in this regard is polyphenols which are found abundantly in berries, fruits and vegetables. Polyphenols show to exert direct and indirect effects in progression of cancer, angiogenesis, proliferation and enhancing resistance to treatment. One of the cellular pathways commonly affected by polyphenols is PI3K/Akt/mTOR pathway, which has far ranging effects on multiple key aspects of cellular growth, metabolism and death. In this review article, evidence regarding the biology of polyphenols in cancer via PI3K/Akt/mTOR pathway is discussed and their application on cancer pathophysiology in various types of human malignancies is shown.
Citations
Apr 25, 2020·IUBMB Life·Mohammad Mirza-Aghazadeh-AttariBahman Yousefi
May 18, 2020·Cells·Qiushuang WuHang Fai Kwok
Aug 9, 2020·OncoTargets and Therapy·Wei HanWei Guan
Aug 31, 2020·Immunology and Cell Biology·Shahin HallajFarhad Jadidi-Niaragh
Dec 20, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Bin XuJunfei Shao
Dec 3, 2020·Nutrients·Carme Grau-BovéAnna Ardévol
Feb 7, 2021·Chemico-biological Interactions·Ainaz MihanfarMaryam Majidinia
Jan 1, 2021·Antioxidants·Marta MenegazziMichela Novelli
Jan 21, 2021·International Journal of Nanomedicine·Yi-Qing ChenPeng-Ke Yan
Dec 17, 2020·Cancer Management and Research·Lixia CaiBin Zheng
Mar 5, 2021·Frontiers in Oncology·Arthur-Quan TranVictoria Bae-Jump
Oct 10, 2020·Seminars in Diagnostic Pathology·Deyin Xing, Oluwole Fadare
May 27, 2021·Cardiovascular Toxicology·Vineetha Vadavanath Prabhakaran, Raghu Kozhiparambil Gopalan
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jelena ŠuranJosipa Vlainić
May 19, 2021·European Journal of Pharmacology·Zhenhui LuoQun Lu
Jun 23, 2021·Organic & Biomolecular Chemistry·Zhiqiong TangLu Liu
Jul 20, 2021·Technology in Cancer Research & Treatment·Wenwen TangLinjiang Song
Jul 11, 2021·Life Sciences·Shahin HallajFarhad Jadidi-Niaragh
Jul 10, 2021·Cancer Investigation·Dongning LiXiaoyan Zhao
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gregoria GregoriouAndreas I Constantinou
Dec 24, 2020·Analytical Cellular Pathology (Amsterdam)·Wen MengQingsong Ding
Sep 12, 2020·Recent Patents on Anti-cancer Drug Discovery·Arunaksharan Narayanankutty