Targeting plasmid-encoded proteins to the antigen presentation pathways

Immunological Reviews
Jens A LeifertJ Lindsay Whitton

Abstract

The antigen presentation pathways constitute a fulcrum on which adaptive immunity is balanced, and their manipulation should allow us to induce designer immune responses. The ease and rapidity with which DNA vaccines can be constructed and altered make them ideal candidates with which to test the various targeting strategies that have been conceived to date. These approaches and the mechanisms that may (or may not) underlie their success are reviewed in this article.

References

Oct 1, 1992·International Immunology·V Calin-LaurensC Rabourdin-Combe
Sep 1, 1989·The Journal of Experimental Medicine·J L Whitton, M B Oldstone
Dec 1, 1995·The Journal of Experimental Medicine·M EggersU H Koszinowski
May 1, 1995·European Journal of Immunology·M L De BruijnP A Peterson
Jun 20, 1995·Proceedings of the National Academy of Sciences of the United States of America·S A ThomsonA Suhrbier
Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·S SandersonN Shastri
Sep 27, 1994·Proceedings of the National Academy of Sciences of the United States of America·E RazM A Yankauckas
Oct 1, 1993·The Journal of Experimental Medicine·H Udono, P K Srivastava
Dec 5, 1995·Proceedings of the National Academy of Sciences of the United States of America·T C WuD M Pardoll
Jun 25, 1996·Biochemical and Biophysical Research Communications·T KageyamaA Moriyama
Oct 1, 1996·Nature Medicine·C CondonL D Falo
Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·A Varshavsky
Aug 1, 1997·Immunology and Cell Biology·A Suhrbier
Aug 26, 1998·Immunology Today·F R CarboneW R Heath
Oct 29, 1998·FEMS Immunology and Medical Microbiology·C AtzoriE Dei-Cas

❮ Previous
Next ❯

Citations

Jan 26, 2008·Nature Reviews. Cancer·Jason RiceFreda K Stevenson
Jan 19, 2006·Clinical Microbiology Reviews·Robert S FujinamiJ Lindsay Whitton
Jan 11, 2007·Molekuliarnaia biologiia·E S StarodubovaV L Karpov
May 4, 2007·The Journal of Clinical Investigation·Eli Gilboa
Feb 18, 2009·BMC Immunology·Diana P GranadosClaude Perreault
Feb 24, 2009·Biotechnology Advances·James A WilliamsClague P Hodgson
Apr 7, 2010·Journal of Biomedicine & Biotechnology·Daniela FiorettiMonica Rinaldi
Oct 8, 2009·International Journal of Cancer. Journal International Du Cancer·Ying WuBin Gao
Oct 13, 2009·Journal of Cellular and Molecular Medicine·M J Loera-AriasR Montes-de-Oca-Luna
Jun 9, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·N CsabaM J Alonso
Jul 5, 2006·International Reviews of Immunology·S BabiukS van Drunen Littel-van den Hurk
May 6, 2015·Journal of Theoretical Biology·Saeed KhaliliAbolfazl Jahangiri
Feb 15, 2011·Virus Research·Alejandro BrunLinda K Dixon
May 8, 2016·Biomaterials·Xiaowei MaXing-Jie Liang
Jul 20, 2005·Expert Review of Vaccines·Maxim PavlenkoPavel Pisa
Jan 1, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Charles H JonesBlaine A Pfeifer
Apr 4, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xueying MaLuis J Sigal
Feb 22, 2017·The Journal of General Virology·Yulia V KuzmenkoVadim L Karpov
Jan 4, 2019·Cell Stress & Chaperones·David H Martínez-PuenteMaría J Loera-Arias
Jul 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·John J DonnellyMargaret A Liu
Dec 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alon MargalitGideon Gross
Aug 8, 2020·Advanced Drug Delivery Reviews·Yaping JuSarah F Hamm-Alvarez
Feb 19, 2021·Journal of Biomolecular Structure & Dynamics·Elham MahdevarVahid Iranpur Mobarakeh
May 1, 2021·Journal of Drug Targeting·David Hernán Martínez-PuenteMaría de Jesús Loera-Arias
Jun 25, 2015·Microbiology Spectrum·Duarte Miguel F Prazeres, Gabriel A Monteiro

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.