Targeting polyamines of parasitic protozoa in chemotherapy

Trends in Parasitology
S MüllerRolf D Walter

Abstract

All parasitic protozoa contain polyamines and in recent years they, and their associated enzymes, have attracted attention as drug targets because they might reveal novel antiparasite therapies. How justified is this approach to drug discovery? In this review, Sylke Müller, Graham Coombs and Rolf Walter summarize the current status of research into drugs that exploit polyamine metabolism of trypanosomatid and malaria parasites, and propose priorities for research into such drugs. This review was inspired by an Expert Meeting entitled 'Polyamine Metabolism of Parasitic Protozoa as a Drug Target'.

References

Apr 1, 1990·Trends in Biochemical Sciences·O Heby, L Persson
Aug 1, 1985·Experimental Parasitology·M R HollingdaleA Sjoerdsma
Oct 1, 1983·Experimental Parasitology·J M GilletP L Mulamba
Jan 1, 1982·Transactions of the Royal Society of Tropical Medicine and Hygiene·J M GilletF Herman
Jan 1, 1995·Annual Review of Pharmacology and Toxicology·C C Wang
Jun 13, 1996·Biochimica Et Biophysica Acta·G H Fukumoto, C V Byus
Jun 1, 1996·The Biochemical Journal·S A Le Quesne, A H Fairlamb
Jun 1, 1996·Antimicrobial Agents and Chemotherapy·C J BacchiY Bühler
Jun 1, 1996·Molecular and Biochemical Parasitology·F LiK M Gottesdiener
Jan 1, 1996·Trends in Biochemical Sciences·S HayashiS Matsufuji
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·F SvenssonL Persson
Jan 1, 1997·Life Sciences·M Kandpal, B L Tekwani
Sep 1, 1997·Molecular and Biochemical Parasitology·J S KeithlyN Yarlett
Jan 28, 1999·The Journal of Biological Chemistry·Y JiangB Ullman
Feb 27, 1999·Biochemical Society Transactions·M R AriyanayagamA H Fairlamb
Apr 27, 1999·The International Journal of Biochemistry & Cell Biology·L M Shantz, A E Pegg
Jul 9, 1999·Bioorganic & Medicinal Chemistry Letters·L CovassinR Poulin
Sep 11, 1999·Parasitology Today·R L Krauth-Siegel, G H Coombs
Mar 8, 2000·Cell Biology International·R M RegueraD Ordóñez
Aug 5, 2000·Molecular and Biochemical Parasitology·M BasselinM P Barrett
Oct 1, 1989·Parasitology Today·M K RiscoeJ H Fitchen

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Citations

Nov 12, 2005·Parasitology Research·D MenezesM A Vannier-Santos
Jan 27, 2004·Bioorganic & Medicinal Chemistry Letters·Guillermo R LabadieMitchell A Avery
May 3, 2005·International Journal for Parasitology·J TavaresA Cordeiro-da-Silva
Feb 22, 2003·Experimental Parasitology·Pablo Arteaga-NietoCarlos Calvo-Méndez
Apr 12, 2002·International Journal for Parasitology·G H Coombs, S Müller
Nov 7, 2003·Lancet·Michael P BarrettSanjeev Krishna
Jun 15, 2012·Journal of Biomolecular Structure & Dynamics·Abhinav GroverDurai Sundar
Jul 1, 2009·Antimicrobial Agents and Chemotherapy·Christophe DardonvilleReto Brun
Nov 15, 2006·Antimicrobial Agents and Chemotherapy·Sushma SinghRentala Madhubala
Oct 1, 2008·Antimicrobial Agents and Chemotherapy·Diego A Goyeneche-PatinoNancy G Saravia
Apr 24, 2004·Antimicrobial Agents and Chemotherapy·Mhairi L StewartMichael P Barrett
Feb 1, 2008·PLoS Neglected Tropical Diseases·Anupam JhingranRentala Madhubala
Apr 22, 2005·Biological Chemistry·Ingrid B MüllerCarsten Wrenger
Jul 24, 2004·The Journal of Parasitology·Sergio Henrique SeabraWanderley de Souza
Apr 26, 2008·Parasitology Research·C MaiaM A Vannier-Santos
Sep 3, 2011·Biochimica Et Biophysica Acta·Barbara KappesPeter Macheroux
Mar 2, 2016·Expert Opinion on Drug Discovery·Bianca K VerlindenLyn-Marié Birkholtz
Dec 28, 2010·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·R B GiordaniM V De Almeida
Apr 22, 2010·International Journal for Parasitology·M Silvina MarcoraIsrael D Algranati
May 6, 2008·Molecular and Biochemical Parasitology·Ingrid B MüllerRolf D Walter
Jun 6, 2007·Toxicon : Official Journal of the International Society on Toxinology·Patrick MerkelMichael Duszenko
Oct 29, 2003·Trends in Parasitology·Simon L Croft, Graham H Coombs
Jan 18, 2006·Free Radical Biology & Medicine·Shane R WilkinsonJohn M Kelly
May 24, 2005·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Rosa María RegueraRafael Balaña-Fouce
Jul 20, 2013·Chemical Biology & Drug Design·Celina N YamanakaMario Steindel
Feb 12, 2013·Biochimica Et Biophysica Acta·Bruno MantaRafael Radi
Oct 26, 2010·Molecular and Biochemical Parasitology·Viswanathan LakshmananJohanna P Daily
Feb 6, 2015·Malaria Journal·Pieter B BurgerAbraham I Louw
Feb 27, 2007·Trends in Parasitology·Fred R Opperdoes, Graham H Coombs

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