Targeting Regulatory T Cells to Treat Patients With Systemic Lupus Erythematosus

Frontiers in Immunology
Masayuki Mizui, George C Tsokos

Abstract

Regulatory T cells (Tregs) are central in integration and maintenance of immune homeostasis. Since breakdown of self-tolerance is a major culprit in the pathogenesis of systemic lupus erythematosus (SLE), restoration of the immune tolerance through the manipulation of Tregs can be exploited to treat patients with SLE. New information has revealed that Tregs besides their role in suppressing the immune response are important in tissue protection and regeneration. Expansion of Tregs with low-dose IL-2 represents an approach to control the autoimmune response. Moreover, control of Treg metabolism can be exploited to restore or improve their function. Here, we summarize the function and diversity of Tregs and recent strategies to improve their function in patients with SLE.

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Citations

Jul 22, 2019·Scandinavian Journal of Immunology·Xiuzhen LiCongjuan Luo
Aug 8, 2019·Current Opinion in Rheumatology·Anne DavidsonMeggan Mackay
Mar 18, 2020·International Journal of Rheumatic Diseases·Ting-Ting LiuAn-Mei Deng
Apr 3, 2020·International Journal of Molecular Sciences·Andreas von KnethenBernhard Brüne
Jul 28, 2020·Frontiers in Immunology·Colton J GarelliJillian M Richmond
Oct 20, 2018·Frontiers in Immunology·Andrew P FerrettiGeorge C Tsokos
Jul 10, 2020·Cell Death & Disease·Masayuki NoguchiJohn A Chiorini
Oct 20, 2018·Frontiers in Immunology·Vaishali R Moulton
Apr 20, 2021·Frontiers in Immunology·Hanna GraßhoffJens Y Humrich
Jul 8, 2021·Cell Reports·Takayuki Katsuyama, Vaishali R Moulton
Nov 4, 2021·Nature Reviews. Rheumatology·Antonios G A KoliosDavid Klatzmann

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Methods Mentioned

BETA
flow cytometry

Clinical Trials Mentioned

NCT03312335
NCT01988506
NCT02084238
NCT02129881
NCT01624077
NCT01210664
NCT02428309

Software Mentioned

Charact
TRANSREG

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