Targeting Siglecs with a sialic acid-decorated nanoparticle abrogates inflammation

Science Translational Medicine
Shaun SpenceChristopher J Scott

Abstract

Sepsis is the most frequent cause of death in hospitalized patients, and severe sepsis is a leading contributory factor to acute respiratory distress syndrome (ARDS). At present, there is no effective treatment for these conditions, and care is primarily supportive. Murine sialic acid-binding immunoglobulin-like lectin-E (Siglec-E) and its human orthologs Siglec-7 and Siglec-9 are immunomodulatory receptors found predominantly on hematopoietic cells. These receptors are important negative regulators of acute inflammatory responses and are potential targets for the treatment of sepsis and ARDS. We describe a Siglec-targeting platform consisting of poly(lactic-co-glycolic acid) nanoparticles decorated with a natural Siglec ligand, di(α2→8) N-acetylneuraminic acid (α2,8 NANA-NP). This nanoparticle induced enhanced oligomerization of the murine Siglec-E receptor on the surface of macrophages, unlike the free α2,8 NANA ligand. Furthermore, treatment of murine macrophages with these nanoparticles blocked the production of lipopolysaccharide-induced inflammatory cytokines in a Siglec-E-dependent manner. The nanoparticles were also therapeutically beneficial in vivo in both systemic and pulmonary murine models replicating inflammatory ...Continue Reading

References

Oct 22, 2003·Intensive Care Medicine·Christian Brun-BuissonUNKNOWN ALIVE Study Group
Jun 16, 2005·Current Opinion in Pharmacology·Paul R Crocker
Feb 6, 2007·Seminars in Immunology·Taro Kawai, Shizuo Akira
Mar 8, 2008·Biochemical and Biophysical Research Communications·Munetoshi AndoShinji Iijima
Jul 16, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Gustavo Matute-BelloThomas R Martin
Jul 17, 2008·Bioconjugate Chemistry·Paul A McCarronChristopher J Scott
Jan 10, 2009·Nature Protocols·Daniel RittirschPeter A Ward
Apr 11, 2009·Trends in Pharmacological Sciences·Mary K O'Reilly, James C Paulson
May 2, 2009·Disease Models & Mechanisms·Julie A Bastarache, Timothy S Blackwell
Sep 2, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jae W LeeMichael A Matthay
Nov 26, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Caroline R BoydCaroline A Jefferies
Feb 6, 2010·Biomaterials·Lucia BondioliMaria A Vandelli
Feb 26, 2010·Blood·Weihsu C ChenJames C Paulson
Mar 27, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·G TosiM A Vandelli
Jul 29, 2010·British Journal of Cancer·J D VeltmanJ G J V Aerts
Jun 11, 2011·Biochemical Pharmacology·Camilla JandusStephan von Gunten
Jul 16, 2011·Leukemia & Lymphoma·Weihsu C ChenJames C Paulson
Aug 31, 2011·Biomaterials·Francois FayChristopher J Scott
Jan 31, 2012·European Journal of Cell Biology·Lucy Kathleen ReissStefan Uhlig
Apr 3, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Keiko MiyazakiReiji Kannagi
Jan 8, 2013·American Journal of Respiratory and Critical Care Medicine·Jae W LeeMichael A Matthay
Feb 16, 2013·Current Opinion in Pulmonary Medicine·Mervyn Singer
Jul 23, 2013·Methods : a Companion to Methods in Enzymology·Brian D HarmsAlexey A Lugovskoy
Feb 18, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·D F McAuleyJ W Lee
May 9, 2014·The Journal of Allergy and Clinical Immunology·Sa'ar MizrahiFrancesca Levi-Schaffer
May 20, 2014·Immunity·Alberto Mantovani, Federica Marchesi
Jul 9, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Norihito KawasakiJames C Paulson
Sep 10, 2014·Molecular Therapy : the Journal of the American Society of Gene Therapy·Daniela SchmidChristopher J Scott
Sep 17, 2014·Proceedings of the National Academy of Sciences of the United States of America·Heinz LäubliAjit Varki
Oct 1, 2014·The New England Journal of Medicine·Daniel F McAuleyUNKNOWN Irish Critical Care Trials Group

❮ Previous
Next ❯

Citations

Feb 26, 2016·Nanomedicine·Felicity SartainAndrew Owen
Apr 18, 2016·Trends in Biochemical Sciences·Christian BüllThomas J Boltje
May 4, 2018·Therapeutic Delivery·Simseok A YukYoon Yeo
Dec 7, 2017·Frontiers in Immunology·Yan-Cun LiuSong-Tao Shou
Jun 19, 2018·Cancers·Emily Rodrigues, Matthew S Macauley
Feb 2, 2019·Current HIV/AIDS Reports·Florent ColombMohamed Abdel-Mohsen
Oct 27, 2017·Proceedings of the National Academy of Sciences of the United States of America·Soracha ThamphiwatanaLiangfang Zhang
Dec 24, 2015·Current Opinion in Allergy and Clinical Immunology·Robert P SchleimerBruce S Bochner
Jun 6, 2018·Frontiers in Molecular Neuroscience·Jian Jing Siew, Yijuang Chern
Aug 14, 2019·Advanced Science·Huize YanKam W Leong
Sep 25, 2019·Cells·Shoib Sarwar SiddiquiHussain Al Zouabi
Jan 23, 2020·Journal of Leukocyte Biology·Jeremy A O'SullivanBruce S Bochner
Jan 8, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Patricia A BlundellRichard J Pleass
May 1, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paul J BelmonteVirginia Smith Shapiro
Mar 24, 2016·Journal of Leukocyte Biology·Ronald L Schnaar
Apr 20, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Robert M ImmorminoTimothy P Moran
Jun 27, 2020·Frontiers in Plant Science·Umashankar ChandrasekaranKai Shu
Nov 18, 2018·Journal of Interdisciplinary Nanomedicine·Lai JiangChristopher J Scott
Jun 14, 2019·Briefings in Bioinformatics·Andrew C LiuKhader Shameer
Jan 24, 2020·Nature Reviews. Drug Discovery·Tamás NémethAttila Mócsai
Jul 30, 2020·Cellular and Molecular Life Sciences : CMLS·Hauke ThieslerHerbert Hildebrandt
Jun 25, 2020·International Journal of Molecular Sciences·Przemyslaw WielgatHalina Car
Aug 28, 2020·Frontiers in Immunology·Jackline Joy Martín LasolaRyan M Pearson
Feb 13, 2017·Engineering in Life Sciences·Ingo de VriesThomas Scheper
Mar 11, 2020·Drug Delivery and Translational Research·Germán BerrecosoMaría José Alonso
Jun 12, 2020·Science Advances·Jianati DawulietiLi Chen
Dec 26, 2018·Frontiers in Immunology·Joyce LübbersYvette van Kooyk
Nov 11, 2020·British Journal of Pharmacology·Alireza TahamtanVahid Salimi
Dec 1, 2020·The FEBS Journal·Heinz LäubliShoib Sarwar Siddiqui
Jan 13, 2021·Proceedings of the National Academy of Sciences of the United States of America·Corleone S DelaverisCarolyn R Bertozzi
Jan 20, 2021·Nature Reviews. Drug Discovery·Benjamin A H Smith, Carolyn R Bertozzi
Jan 6, 2021·Journal of Biomedical Science·Yaw-Wen HsuLee-Young Chau
Dec 19, 2020·Cells·María Pia LenzaJune Ereño-Orbea
Jan 9, 2021·Journal of Biomedical Science·Amit PantThirumala Govender
Feb 13, 2021·Biomolecules·Cláudia D RaposoM Teresa Barros

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here