PMID: 8939707Nov 1, 1996Paper

Targeting signal transduction in the discovery of antiproliferative drugs

Chemistry & Biology
A R Saltiel, T K Sawyer

Abstract

Derangements in the signal transduction pathways controlling cell growth can lead to cancer. Two areas of growth factor signaling offer novel opportunities for therapeutic intervention: protein-protein interactions and phosphorylation cascades.

References

Aug 7, 1992·Cell·T Hunter, M Karin
Apr 1, 1995·Nature Medicine·J E Karp, S Broder
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·D T DudleyA R Saltiel
Sep 8, 1995·The Journal of Biological Chemistry·S B WatersJ E Pessin
Mar 12, 1993·Cell·Z SongyangR J Lechleider
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Dec 16, 1993·Nature·M S Boguski, F McCormick
Jan 19, 1996·Journal of Medicinal Chemistry·J T HuntV Manne
Jul 1, 1996·Nature Structural Biology·J RahuelM G Grütter

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Citations

Jul 25, 2003·Biochemical and Biophysical Research Communications·Peng LiPeter P Roller
May 27, 2003·Biopolymers·Feng-Di T Lung, Jya-Yin Tsai
Nov 15, 2001·Anti-cancer Drugs·T SchöndorfC M Kurbacher
Jan 1, 1999·Bioorganic & Medicinal Chemistry Letters·K J AlligoodD D Sternbach
Jun 20, 1998·Journal of Medicinal Chemistry·C García-EcheverríaG Caravatti
Sep 9, 2006·The Journal of Organic Chemistry·Sheng JiangPeter P Roller

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