Targeting Super-Enhancers for Disease Treatment and Diagnosis

Molecules and Cells
Ha Youn Shin

Abstract

The transcriptional regulation of genes determines the fate of animal cell differentiation and subsequent organ development. With the recent progress in genome-wide technologies, the genomic landscapes of enhancers have been broadly explored in mammalian genomes, which led to the discovery of novel specific subsets of enhancers, termed super-enhancers. Super-enhancers are large clusters of enhancers covering the long region of regulatory DNA and are densely occupied by transcription factors, active histone marks, and co-activators. Accumulating evidence points to the critical role that super-enhancers play in cell type-specific development and differentiation, as well as in the development of various diseases. Here, I provide a comprehensive description of the optimal approach for identifying functional units of super-enhancers and their unique chromatin features in normal development and in diseases, including cancers. I also review the recent updated knowledge on novel approaches of targeting super-enhancers for the treatment of specific diseases, such as small-molecule inhibitors and potential gene therapy. This review will provide perspectives on using super-enhancers as biomarkers to develop novel disease diagnostic tools ...Continue Reading

Citations

Apr 12, 2019·Heart Failure Reviews·Rachel A MinerathChad E Grueter
Jul 19, 2020·International Journal of Molecular Sciences·Bart G JonesJulia L Hurwitz
Jul 28, 2020·Frontiers in Cell and Developmental Biology·Jian QuZhihong Li
May 21, 2019·Frontiers in Pharmacology·Yi HeQing Liu
Oct 7, 2018·Journal of Mammary Gland Biology and Neoplasia·Kyung Hyun YooHa Youn Shin
Sep 29, 2020·Cancer Management and Research·Jianlong ZhouWenhua Huang
Feb 26, 2021·Frontiers in Oncology·Zhihui LiuCarol J Thiele

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Methods Mentioned

BETA
immunoprecipitation
acetylation
ChIP-seq
RNA-seq
xenograft

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