Aug 6, 2019

Targeting Synaptic Plasticity in Experimental Models of Alzheimer's Disease

Frontiers in Pharmacology
D MangoRobert Nisticò

Abstract

Long-term potentiation (LTP) and long-term depression (LTD) of hippocampal synaptic transmission represent the principal experimental models underlying learning and memory. Alterations of synaptic plasticity are observed in several neurodegenerative disorders, including Alzheimer's disease (AD). Indeed, synaptic dysfunction is an early event in AD, making it an attractive therapeutic target for pharmaceutical intervention. To date, intensive investigations have characterized hippocampal synaptic transmission, LTP, and LTD in in vitro and in murine models of AD. In this review, we describe the synaptic alterations across the main AD models generated so far. We then examine the clinical perspective of LTP/LTD studies and discuss the limitations of non-clinical models and how to improve their predictive validity in the drug discovery process.

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Mentioned in this Paper

Study
Long Term Depression
Action Potentials
Synaptic Transmission
Alzheimer's Disease
Neuronal Plasticity
Synapses
Disease Transmission
Learning
Long-Term Potentiation

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