Targeting tacrolimus to deeper layers of skin with improved safety for treatment of atopic dermatitis

International Journal of Pharmaceutics
Pallavi V Pople, Kamalinder K Singh

Abstract

Atopic dermatitis (AD) is chronically relapsing eczematous skin disorder having significant impact worldwide. Tacrolimus is the drug-of-choice which inhibits T-cell activation resulting in suppression of inflammation. However, despite being effective, most common adverse events of tacrolimus are low-and-variable bioavailability, burning sensation and pruritus at application site, which prompt for development of novel carrier that could effectively target tacrolimus to site-of-action without producing undesirable side-effects. Tacrolimus-loaded lipid-nanoparticles (T-LN) were prepared and optimized. DSC and FT-IR have been employed to study drug-excipient incompatibility and encapsulation of drug in lipid which was further confirmed by (1)H NMR. In vitro studies revealed much higher drug release, skin penetration and enhanced skin accumulation as compared to reference Protopic. In vitro and in vivo occlusion studies demonstrated similar occlusiveness for T-LN and reference however; T-LN showed significantly higher drug levels penetrating into deeper skin layers where dendritic cells responsible for immunopathogenesis of AD mainly reside. In-vivo skin retention demonstrated 3.36, 30.81 and 28.68-times higher stratum corneum, epid...Continue Reading

References

Jan 1, 1994·Dermatology : International Journal for Clinical and Investigative Dermatology·A I Lauerma, H I Maibach
Aug 1, 1997·Archives of Dermatological Research·L NorlénB Forslind
Aug 15, 1998·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·A zur MühlenW Mehnert
May 9, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·V JenningS H Gohla
Aug 15, 2002·International Journal of Pharmaceutics·S SantoyoM J Blanco-Príeto
Aug 15, 2002·International Journal of Pharmaceutics·S Wissing, R Müller
Jan 22, 2003·The British Journal of Dermatology·M FurueT Koga
Feb 21, 2003·Biomaterials·DongZhi HouChangHong Zhu
Jul 3, 2003·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Sylvia A Wissing, Rainer H Müller
Nov 7, 2003·International Journal of Pharmaceutics·Kazunari YamashitaToshikiro Kimura
Jan 17, 2004·International Journal of Pharmaceutics·H YoshidaR Ibuki
May 26, 2004·International Journal of Pharmaceutics·E B SoutoR H Müller
May 24, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Alf LamprechtYoshiaki Kawashima
Nov 22, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·S Lombardi BorgiaM Schäfer-Korting
Jan 18, 2006·AAPS PharmSciTech·Loice KikwaiMandip Singh
Jul 11, 2006·Current Allergy and Asthma Reports·Jonathan M Spergel, Donald Y M Leung
Sep 19, 2006·International Journal of Pharmaceutics·Jie LiuXiangliang Yang
Feb 9, 2007·AAPS PharmSciTech·Pallavi V Pople, Kamalinder K Singh
Jun 5, 2007·Advanced Drug Delivery Reviews·Monika Schäfer-KortingHans-Christian Korting
Jun 8, 2007·Advanced Drug Delivery Reviews·Anna Radomska-Soukharev
Sep 20, 2007·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Hagalavadi Nanjappa ShivakumarSinnathambi Arulmozhi
Nov 11, 2008·International Journal of Pharmaceutics·Jana PardeikeRainer H Müller
May 2, 2009·Archives of Pharmacal Research·Dubok Choi, Hoon Cho

❮ Previous
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Citations

Aug 21, 2013·International Journal of Pharmaceutics·Chin-Tung WuHsin-Sheng Tsay
Oct 17, 2014·Nanomedicine·Mona Ma Abdel-MottalebAlf Lamprecht
Mar 13, 2014·International Journal of Nanomedicine·Renata V ContriSilvia S Guterres
Aug 21, 2013·Expert Opinion on Therapeutic Patents·Fei LiuRuo-Yun Tan
May 9, 2012·Expert Opinion on Drug Delivery·Madhu GuptaSuresh P Vyas
Mar 8, 2012·Expert Opinion on Drug Delivery·Carmelo Puglia, Francesco Bonina
Dec 19, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Pallavi V Pople, Kamalinder K Singh
Jun 19, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Guiling LiYan Liu
May 24, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Punit P ShahMandip Singh
Jun 15, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·L B JensenH M Nielsen
Mar 31, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Pallavi V Pople, Kamalinder K Singh
Sep 8, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Cristina G VenturiniSilvia S Guterres
Jul 19, 2012·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E Gros, N Novak
Jul 7, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Andreas Lauterbach, Christel C Müller-Goymann
Aug 15, 2012·Pharmaceutical Development and Technology·Catarina RosadoCatarina P Reis
Nov 26, 2010·International Journal of Pharmaceutics·Alexandra S B GoebelJohannes Wohlrab
Aug 16, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Slavomira DoktorovováEliana B Souto
Sep 7, 2016·Colloids and Surfaces. B, Biointerfaces·Mei ShaoSyed Nasir Abbas Bukhari
Oct 5, 2016·Nanomedicine : Nanotechnology, Biology, and Medicine·Hannah PischonLars Mundhenk
Nov 22, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jihui ZhaoNianping Feng
Dec 23, 2016·The Journal of Physical Chemistry. B·Muhammad Faizan NazarMuhammad Zubair
Jun 26, 2018·Drug Development and Industrial Pharmacy·Vandita KakkarKamalinder K Singh
Aug 2, 2018·Expert Opinion on Drug Delivery·Huiling Mu, René Holm
Oct 3, 2014·Biological & Pharmaceutical Bulletin·Sang Gon LeeYoung Wook Choi
Nov 28, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Roxana JijieSabine Szunerits
Aug 21, 2020·Expert Opinion on Drug Delivery·Estefânia Vangelie Ramos CamposDaniele Ribeiro de Araujo
Jul 28, 2019·Journal of Pharmaceutical Sciences·Monika KauravRavi Shankar Pandey
Aug 16, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Muhammad Faizan NazarAzwan Mat Lazim
Sep 10, 2021·International Journal of Pharmaceutics·Khushali ParekhTejal Mehta

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