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Targeting tauopathy with engineered tau-degrading intrabodies

Molecular Neurodegeneration

Oct 22, 2019

Gilbert GallardoDavid. M. Holtzman

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Abstract

The accumulation of pathological tau is the main component of neurofibrillary tangles and other tau aggregates in several neurodegenerative diseases, referred to as tauopathies. Recently, immunotherapeutic approaches targeting tau have been demonstrated to be beneficial in decreasing ta...read more

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Dependovirus
Lysosomes
Mice, Transgenic
Nerve Degeneration
Neurons
Pathology
Ubiquitin
Tau Proteins
Intracellular
Multicatalytic endopeptidase complex
5
1
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Targeting tauopathy with engineered tau-degrading intrabodies

Molecular Neurodegeneration

Oct 22, 2019

Gilbert GallardoDavid. M. Holtzman

PMID: 31640765

DOI: 10.1186/s13024-019-0340-6

Abstract

The accumulation of pathological tau is the main component of neurofibrillary tangles and other tau aggregates in several neurodegenerative diseases, referred to as tauopathies. Recently, immunotherapeutic approaches targeting tau have been demonstrated to be beneficial in decreasing ta...read more

Mentioned in this Paper

Dependovirus
Lysosomes
Mice, Transgenic
Nerve Degeneration
Neurons
5
1

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