Targeting TGF-β Signaling in Kidney Fibrosis

International Journal of Molecular Sciences
Yoshitaka Isaka

Abstract

Renal fibrosis is the final common pathway of numerous progressive kidney diseases, and transforming growth factor-β (TGF-β) has an important role in tissue fibrosis by up-regulating matrix protein synthesis, inhibiting matrix degradation, and altering cell-cell interaction. Many strategies targeting TGF-β, including inhibition of production, activation, binding to the receptor, and intracellular signaling, have been developed. Some of them were examined in clinical studies against kidney fibrosis, and some are applied to other fibrotic diseases or cancer. Here, I review the approaches targeting TGF-β signaling in kidney fibrosis.

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Citations

Jun 23, 2020·Journal of Cellular and Molecular Medicine·Sung-Je MoonJung Hwan Hwang
Oct 17, 2019·International Journal of Molecular Sciences·Hoon-In ChoiSoo Wan Kim
Dec 18, 2019·Cells·Joanna BoguslawskaAgnieszka Piekielko-Witkowska
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Methods Mentioned

BETA
biopsy
transfection
transgenic
antisense oligodeoxynucleotides
sedation

Clinical Trials Mentioned

NCT01113801
NCT01371305

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