Targeting the adventitial microenvironment in pulmonary hypertension: A potential approach to therapy that considers epigenetic change.

Pulmonary Circulation
K R StenmarkKarim C El Kasmi

Abstract

Experimental data indicate that the adventitial compartment of blood vessels, in both the pulmonary and systemic circulations, like the connective tissue stroma in tissues throughout the body, is a critical regulator of vessel wall function in health and disease. It is clear that adventitial cells, and in particular the adventitial fibroblast, are activated early following vascular injury, and play essential roles in regulating vascular wall structure and function through production of chemokines, cytokines, growth factors, and reactive oxygen species (ROS). The recognition of the ability of these cells to generate and maintain inflammatory responses within the vessel wall provides insight into why vascular inflammatory responses, in certain situations, fail to resolve. It is also clear that the activated adventitial fibroblast plays an important role in regulating vasa vasorum growth, which can contribute to ongoing vascular remodeling by acting as a conduit for delivery of inflammatory and progenitor cells. These functions of the fibroblast clearly support the idea that targeting chemokine, cytokine, adhesion molecule, and growth factor production in activated fibroblasts could be helpful in abrogating vascular inflammatory r...Continue Reading

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Citations

Dec 12, 2012·Annual Review of Physiology·Kurt R StenmarkMaria G Frid
Aug 7, 2013·Journal of Neurovirology·Maria A Nagel
Jan 27, 2015·Pulmonary Circulation·Vadim ShlyonskyFrédérique Mies
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Mar 25, 2014·Pulmonary Pharmacology & Therapeutics·Hatem AlkhouriMichael Schuliga
Dec 25, 2015·American Journal of Respiratory Cell and Molecular Biology·Lydie Plecitá-HlavatáKurt R Stenmark
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Jun 20, 2018·The Journal of Physiology·Cheng-Jun HuKurt R Stenmark
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Nov 25, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Steven C PuglieseKurt R Stenmark
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Aug 28, 2021·International Journal of Environmental Research and Public Health·Manju PadmasekarSoni Savai Pullamsetti
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Methods Mentioned

BETA
glycosylation
glycosolation
transgenic
laser capture microdissection
acetylation
histone acetylation

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