Targeting the cholinergic system in Parkinson's disease

Acta Pharmacologica Sinica
Changliang Liu

Abstract

Motor control in the striatum is an orchestra played by various neuronal populations. Loss of harmony due to dopamine deficiency is considered the primary pathological cause of the symptoms of Parkinson's disease (PD). Recent progress in experimental approaches has enabled us to examine the striatal circuitry in a much more comprehensive manner, not only reshaping our understanding of striatal functions in movement regulation but also leading to new opportunities for the development of therapeutic strategies for treating PD. In addition to dopaminergic innervation, giant aspiny cholinergic interneurons (ChIs) within the striatum have long been recognized as a critical node for balancing dopamine signaling and regulating movement. With the roles of ChIs in motor control further uncovered and more specific manipulations available, striatal ChIs and their corresponding receptors are emerging as new promising therapeutic targets for PD. This review summarizes recent progress in functional studies of striatal circuitry and discusses the translational implications of these new findings for the treatment of PD.

References

Jul 1, 1990·Trends in Neurosciences·M R DeLong
Oct 1, 1989·Trends in Neurosciences·R L AlbinJ B Penney
Dec 1, 1971·European Journal of Clinical Pharmacology·R K WhyteP Armitage
Sep 23, 1994·Science·A M GraybielM Kimura
Nov 1, 1995·Neuropharmacology·L SoliakovS Wonnacott
Feb 1, 1997·Trends in Neurosciences·S Wonnacott
Mar 14, 1997·Science·W SchultzP R Montague
Feb 11, 1998·Physiological Reviews·C MissaleM G Caron
Aug 6, 1998·Neuroscience·D R SmithM Gallagher
Oct 1, 1998·Neurobiology of Learning and Memory·A M Graybiel
Oct 15, 1998·The New England Journal of Medicine·A E Lang, A M Lozano
Jul 14, 2000·Physiological Reviews·O HikosakaR Kawagoe
May 23, 2001·Chemical Research in Toxicology·K P CastagnoliN Castagnoli
Nov 19, 2002·Journal of Neurobiology·Fu-Ming ZhouJohn A Dani
Feb 8, 2003·Annual Review of Neuroscience·Richard Mayeux
Dec 23, 2003·The European Journal of Neuroscience·Michelle M Nicolle, Mark G Baxter
May 18, 2004·Nature Neuroscience·Hui Zhang, David Sulzer
May 18, 2004·Nature Neuroscience·Margaret E Rice, Stephanie J Cragg
Aug 28, 2004·Trends in Neurosciences·Maryka Quik

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Citations

Mar 24, 2020·Acta Pharmacologica Sinica·Xue-Chu Zhen, Hong-Yuan Chu
May 26, 2020·CNS & Neurological Disorders Drug Targets·Andrew SchneiderYoussef Sari
May 19, 2021·Neurotoxicity Research·Yousef TizabiMichael Aschner
Jul 17, 2021·Neurochemistry International·Sidrah Tariq KhanAhmed Al-Harrasi
Jul 31, 2021·Frontiers in Aging Neuroscience·Anna GasiorowskaGrazyna Niewiadomska
Aug 29, 2021·Pharmaceuticals·E Maruthi Prasad, Shih-Ya Hung

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