Targeting the IL-23/IL-17 Pathway in Psoriasis: the Search for the Good, the Bad and the Ugly

American Journal of Clinical Dermatology
Sofie MylleNanja van Geel

Abstract

New promising treatments have been developed for psoriasis that target different parts of the interleukin (IL)-23/IL-17 pathway. This approach is believed to be more disease specific, and sparing the T helper 1 pathway might prevent serious long-term adverse events. Moreover, superior Psoriasis Area and Severity Index improvements are observed, which has redefined treatment goals in psoriasis. The new molecules can be divided into different categories, according to the target: blocking agents can target the upstream cytokine IL-23 or the downstream IL-17. In the latter, a variety of targets exist, such as the ligands IL-17A and IL-17F, or a combination thereof, or a subunit of the receptor, IL-17RA. Each target seems to have its own set of advantages and pitfalls, which will impact the treatment decision in clinical practice. In this review, we summarize the current knowledge on the different inhibitors of the IL-23/IL-17 pathway. Furthermore, we briefly discuss the role of IL-17 in other diseases and comorbidities. Finally, we discuss how comprehensive knowledge is needed for the prescribing physician in order to make the most appropriate therapeutic choice for each individual patient.

References

Jan 1, 1990·Cytokine·A J GearingR D Camp
Dec 1, 1990·Journal of the American Academy of Dermatology·K D CooperO Baadsgaard
Jul 1, 1988·Journal of the American Academy of Dermatology·H H RoenigkG D Weinstein
Jan 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·H LiW I Wood
Feb 29, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M ZiolkowskaW Maslinski
May 30, 2001·Journal of Dermatological Science·H DuanM Furue
Dec 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bruno GranAbdolmohamad Rostami
Jul 9, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chia-Hui LoMi-Hua Tao
Dec 10, 2003·The Journal of Experimental Medicine·Craig A MurphyDaniel J Cua
Oct 16, 2004·Immunity·Jay K Kolls, Anders Lindén
Aug 6, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alice B GottliebJames G Krueger
Feb 17, 2006·European Journal of Immunology·Marieke A HoeveFrank A W Verreck
Nov 1, 1990·The Journal of Investigative Dermatology·G D WeinsteinJ L McCullough
Feb 23, 2007·Nature·Michelle A LowesJames G Krueger
Mar 16, 2007·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Xu'e ChenJiawen Li
Aug 7, 2007·Nature Immunology·Nicholas J WilsonRene de Waal Malefyt
Aug 21, 2007·Journal of the American Academy of Dermatology·Dorothea C Torti, Steven R Feldman
Nov 28, 2007·The Journal of Experimental Medicine·Lisa C ZabaJames G Krueger
Feb 12, 2008·Nature Medicine·Shean J AujlaJay K Kolls
Apr 16, 2008·The Journal of Experimental Medicine·Xuexian O YangChen Dong
Oct 3, 2008·The Journal of Investigative Dermatology·Hideaki WatanabeMasafumi Iijima
Nov 20, 2008·The British Journal of Dermatology·C JohansenK Kragballe
Jan 24, 2009·Immunological Reviews·Yoichiro IwakuraHarumichi Ishigame
Nov 10, 2009·The Journal of Allergy and Clinical Immunology·Lisa C ZabaJames G Krueger
Jan 15, 2010·The New England Journal of Medicine·Christopher E M GriffithsUNKNOWN ACCEPT Study Group
Feb 24, 2010·Journal of Clinical Immunology·Rajita PappuYan Hu
Jun 19, 2010·Nature Reviews. Immunology·Daniel J Cua, Cristina M Tato
Aug 11, 2010·The Journal of Clinical Investigation·Partha S BiswasAlessandra B Pernis
Oct 14, 2011·Nature Immunology·Vladimir Ramirez-CarrozziRajita Pappu
Oct 25, 2011·Experimental Dermatology·Masataka ArakawaTakashi Hashimoto
Mar 30, 2012·The New England Journal of Medicine·Kim A PappScott Baumgartner
Apr 21, 2012·Growth Factors·Arseniy E Yuzhalin, Anton G Kutikhin
Jan 30, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew JohnstonNicole L Ward

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Citations

Aug 29, 2019·Expert Review of Clinical Pharmacology·Chuanlan Gu, Junyi Yang

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