Targeting the immune system in non-small-cell lung cancer: bridging the gap between promising concept and therapeutic reality.

Clinical Lung Cancer
Ronan J KellyGiuseppe Giaccone

Abstract

Developing effective immunotherapy for lung cancer is a daunting but hugely attractive challenge. Until recently, non-small-cell lung cancer (NSCLC) was thought of as a nonimmunogenic tumor, but there is now evidence highlighting the integral role played by both inflammatory and immunologic responses in lung carcinogenesis. Despite recent encouraging preclinical and phase I/II data, there are a paucity of phase III trials showing a clear clinical benefit for vaccines in lung cancer. There are many difficulties to overcome before the development of a successful therapy. Perhaps a measurable immune response may not translate into a clinically meaningful or radiologic response. Patient selection may also be a problem for ongoing clinical studies. The majority of trials for lung cancer vaccines are focused on patients with an advanced stage of the disease; however, the ideal candidates may be patients with a lower tumor burden and stage I or II disease. Selecting the exact antigens to target is also difficult. It will likely require multiple epitopes of a diverse set of genes restricted to multiple haplotypes to generate a truly effective vaccine that is able to overcome the various immunologic escape mechanisms that tumors use. Th...Continue Reading

References

Aug 1, 1995·The Journal of Experimental Medicine·M F Krummel, J P Allison
Aug 1, 1994·Immunity·T L WalunasJ A Bluestone
Apr 2, 1996·Proceedings of the National Academy of Sciences of the United States of America·D M KlinmanA M Krieg
Jun 1, 1996·The Journal of Experimental Medicine·M F Krummel, J P Allison
Jun 1, 1997·Current Opinion in Immunology·C van Kooten, J Banchereau
Mar 25, 1999·Acta Crystallographica. Section D, Biological Crystallography·X L SunE N Baker
Jun 24, 2000·Clinical Immunology : the Official Journal of the Clinical Immunology Society·D L Farber
Apr 26, 2001·The Journal of Biological Chemistry·M DohadwalaS M Dubinett
Jun 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·L FongE G Engleman
Jul 17, 2001·Immunology·R LechlerG Lombardi
Mar 21, 2002·Cancer Immunology, Immunotherapy : CII·Tsuyoshi ItohHisakazu Yamagishi
Mar 23, 2002·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Hiroyuki TsudaMasaaki Ligo
May 31, 2002·Blood·Brian F Skinnider, Tak W Mak
Aug 1, 2002·Proceedings of the National Academy of Sciences of the United States of America·Senitiroh Hakomori
Oct 2, 2002·European Journal of Immunology·Claire N ManzottiDavid M Sansom
Mar 14, 2003·Current Opinion in Immunology·Gerold SchulerRalph M Steinman
Mar 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Adriana CarrLuis Enrique Fernández
Mar 26, 2003·Cytokine & Growth Factor Reviews·WanJun Chen, Sharon M Wahl
Sep 10, 2003·International Journal of Molecular Medicine·Keiichi KontaniShozo Fujino
Dec 3, 2003·Cancer Immunology, Immunotherapy : CII·Lee D CranmerEvan M Hersh
Dec 24, 2003·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·W SienelB Passlick
Feb 19, 2004·Journal of the National Cancer Institute·John NemunaitisKristen Hege
Jul 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Edward A HirschowitzJohn Yannelli
Aug 24, 2004·The Journal of Biological Chemistry·Li YinDonald Kufe
Jan 22, 2005·Current Opinion in Genetics & Development·Neil A Bhowmick, Harold L Moses
Apr 20, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael A MorseH Kim Lyerly
Sep 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles ButtsMartin Palmer
Sep 30, 2005·Investigational New Drugs·Teresa G HayesAtul Varadhachary
Nov 22, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ali O GureNasser K Altorki
Dec 2, 2005·Clinical & Experimental Metastasis·Jennifer J RahnJudith C Hugh

❮ Previous
Next ❯

Citations

Sep 6, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Runbo ZhongHua Zhong
Jan 8, 2015·Journal of Personalized Medicine·Anastasios Dimou, Vassiliki Papadimitrakopoulou
Feb 11, 2016·Immunotherapy·Bing Xia, Roy S Herbst
Aug 31, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Frances A ShepherdGeorge R Blumenschein
Nov 20, 2015·American Journal of Respiratory and Critical Care Medicine·Emma M ConwayKevin L Bennewith
Oct 23, 2013·Future Oncology·Sarah Declerck, Johan Vansteenkiste
Sep 11, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiao ZhouJianfang Xu
Oct 18, 2016·Journal of Immunology Research·Gustavo Dix Junqueira PintoSérgio Vicente Serrano
May 2, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas J LynchMartin Reck
Apr 19, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Daniele MarchioniLivio Presutti
Sep 13, 2020·Cancer Immunology, Immunotherapy : CII·Asmaa M ZahranAmal Rayan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Related Papers

Annals of Oncology : Official Journal of the European Society for Medical Oncology
L DecosterJ F Vansteenkiste
Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Kazuhiro KakimiHiromi Wada
Seminars in Oncology
Bridget P Keenan, Elizabeth M Jaffee
Current Opinion in Investigational Drugs
Joanne Lysaght, Stephen Todryk
© 2021 Meta ULC. All rights reserved