Targeting the integrin interactome in human disease

Current Opinion in Cell Biology
Miguel Vicente-Manzanares, F Sánchez-Madrid

Abstract

Integrins comprise one of the most important families of cell-cell or cell-matrix adhesion receptors. Integrin interaction with their extracellular ligands is tunable by microenvironment signals, such as chemokines and growth factors, which modulate their interaction with other transmembrane proteins and cytoplasmic interactors. Integrins are important in different disease contexts, particularly inflammatory diseases and cancer. Clinical trials targeting integrins began in the early 2000s, leading to an increasingly clear picture: agents against integrins and their interactome control inflammatory diseases; whereas their efficacy as anti-cancer targets remains dubious. Here, we discuss the success of integrin targeting to treat autoimmunity and its failure in cancer, which is rooted in the plasticity and adaptability of the cancer cell.

Citations

Apr 7, 2019·Biology Open·Viju Vijayan PillaiVimal Selvaraj
May 6, 2019·Cancers·Rafael PeláezIgnacio M Larrayoz
Aug 23, 2019·Scientific Reports·Andreas SchedlbauerSilvia Dossena
Mar 1, 2019·Frontiers in Endocrinology·Florencia CayrolGraciela A Cremaschi
Nov 15, 2018·Frontiers in Cell and Developmental Biology·Noa Beatriz Martín-CófrecesFrancisco Sánchez-Madrid
May 28, 2019·International Journal of Molecular Sciences·Suni LeeTakemi Otsuki
Apr 29, 2020·Annual Review of Immunology·Nico GhilardiAndrew C Chan
May 30, 2019·Cancers·C Michael DiPersio, Livingston Van De Water
Jul 25, 2019·Cancers·Begoña Alday-ParejoCurzio Rüegg
May 19, 2021·Cellular Signalling·Yasaswi Gayatri Mishra, Bramanandam Manavathi

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