Targeting the intestinal lymphatic system: a versatile path for enhanced oral bioavailability of drugs

Expert Opinion on Drug Delivery
Renuka Suresh ManaguliSrinivas Mutalik

Abstract

The major challenge of first pass metabolism in oral drug delivery can be surmounted by directing delivery toward intestinal lymphatic system (ILS). ILS circumvents the liver and transports drug directly into systemic circulation via thoracic duct. Lipid and polymeric nanoparticles are transported into ILS through lacteal and Peyer's patches. Moreover, surface modification of nanoparticles with ligand which is specific for Peyer's patches enhances the uptake of drugs into ILS. Bioavailability enhancement by lymphatic uptake is an advantageous approach adopted by scientists today. Therefore, it is important to understand clear insight of ILS in targeted drug delivery and challenges involved in it. Current review includes an overview of ILS, factors governing lymphatic transport of nanoparticles and absorption mechanism of lipid and polymeric nanoparticles into ILS. Various ligands used to target Peyer's patch and their conjugation strategies to nanoparticles are explained in detail. In vitro and in vivo models used to assess intestinal lymphatic transport of molecules are discussed further. Although ILS offers a versatile pathway for nanotechnology based targeted drug delivery, extensive investigations on validation of the lymph...Continue Reading

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Citations

Jan 7, 2020·Annual Review of Food Science and Technology·David Julian McClements
Jan 6, 2019·Nutrients·Ching-Yun HsuJia-You Fang
Jul 25, 2019·Journal of Clinical Medicine·Ibon Eguiluz-GraciaCarmen Rondón
Jul 28, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Feiyang Deng, You Han Bae
Apr 27, 2021·Expert Opinion on Drug Delivery·Gabriel Silva Marques BorgesLucas Antônio Miranda Ferreira
Jan 18, 2022·Pharmaceutical Development and Technology·Takayuki YoshidaHiromu Kondo

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