Targeting the methionine cycle for melanoma therapy with 3-O-(3,4,5-trimethoxybenzoyl)-(-)-epicatechin

International Journal of Cancer. Journal International Du Cancer
Luís Sánchez-del-Campo, José Neptuno Rodríguez-López

Abstract

The higher expression of methionine cycle genes in melanoma cells than in normal melanocytes may be related with increased protein synthesis and transmethylation reactions and the subsequent need for high levels of methionine. 3-O-(3,4,5-trimethoxybenzoyl)-(-)-epicatechin (TMECG), a trimethoxy derivative of epicatechin-3-gallate (ECG), effectively suppressed proliferation of melanoma cells in cultures by inducing apoptosis. TMECG modulates the expression of genes involved in methionine metabolism, cellular methylation and glutathione synthesis in melanoma cells. TMECG treatment of melanoma cells resulted in the downregulation of antiapoptotic Bcl-2, the upregulation of proapoptotic Bax and the activation of caspase-3; however, it did not induce the expression of the apoptosis protease-activating factor-1 (Apaf-1). Having elucidated the effects of TMECG on the melanoma methionine cycle, we designed therapeuthical strategies to increase its effectiveness. Combinations of TMECG with S-adenosylmethionine or compounds that modulate the intracellular concentration of adenosine strongly increase the antiproliferative effects of TMECG. The ability of TMECG to target multiple aspects related with melanoma survival, with a high degree of...Continue Reading

References

May 1, 1983·British Journal of Cancer·J GaukrogerR Mackie
Oct 1, 1980·The Journal of Investigative Dermatology·D W KufeH T Abelson
Nov 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J CaiS C Lu
Jan 1, 1997·Pharmacology & Therapeutics·J M MatoM A Pajares
Jul 29, 1998·Chemico-biological Interactions·M E Anderson
Feb 13, 1999·Nature Genetics·P A Jones, P W Laird
Sep 27, 2000·Human Molecular Genetics·T H Bestor
Dec 2, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E R García-TrevijanoM A Avila
Apr 6, 2001·Cellular and Molecular Life Sciences : CMLS·T Thomas, T J Thomas
Dec 1, 2001·Pharmacology & Therapeutics·R Tabrizchi, S Bedi
Jan 12, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elena ObradorJosé M Estrela
Aug 3, 2002·Oncogene·Martin Widschwendter, Peter A Jones
Oct 26, 2002·Cancer Cell·Alan N Houghton, David Polsky
Oct 25, 2003·Oncogene·Rongbao Zhao, I David Goldman
Oct 31, 2003·Cancer Treatment Reviews·E CellarierP Chollet
Apr 23, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Frank L MeyskensHoda Anton-Culver
Dec 21, 2004·International Journal of Cancer. Journal International Du Cancer·Minakshi NihalGary S Wood
Mar 23, 2005·Cancer Research·Enma Navarro-PeránJosé Neptuno Rodríguez-López
Apr 21, 2005·The Journal of Clinical Investigation·Yakov ChudnovskyAmy E Adams
Sep 17, 2005·Cancer Research·Mark D Lucock, Paul D Roach
Feb 17, 2006·The New England Journal of Medicine·Henry Koon, Michael Atkins
Aug 9, 2007·The International Journal of Biochemistry & Cell Biology·Enma Navarro-PeránJosé Neptuno Rodríguez-López
Mar 8, 2008·Journal of Medicinal Chemistry·Luís Sánchez-del-CampoJosé Neptuno Rodríguez-López

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Citations

Jun 6, 2009·Pigment Cell & Melanoma Research·Luís Sánchez-del-CampoJosé Neptuno Rodríguez-López
Jan 8, 2010·International Journal of Molecular Sciences·Luís Sánchez-del-CampoJosé Neptuno Rodríguez-López
Jul 19, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Magalí Sáez-AyalaJosé Neptuno Rodríguez-López
Apr 10, 2012·Experimental Cell Research·Magalí Sáez-AyalaJosé Neptuno Rodríguez-López
Jun 22, 2010·Journal of Cellular Biochemistry·Luís Sánchez-del-CampoJosé Neptuno Rodríguez-López
Apr 8, 2016·Cell Death & Disease·M F MontenegroJ N Rodríguez-López
Jul 30, 2014·BMC Cancer·María F MontenegroJosé Neptuno Rodríguez-López
Jan 29, 2014·Oncogene·M F MontenegroJ N Rodríguez-López
Jul 12, 2016·Toxins·Manel B HammoudaKhadija Essafi-Benkhadir
Apr 2, 2021·Journal of Experimental & Clinical Cancer Research : CR·Luis Sánchez-Del-CampoJosé Neptuno Rodríguez-López
Apr 11, 2009·Molecular Pharmaceutics·Luís Sánchez-del-CampoJosé Neptuno Rodríguez-López

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