Targeting the Mitochondrial Potassium Channel Kv1.3 to Kill Cancer Cells: Drugs, Strategies, and New Perspectives

SLAS Discovery
Elena ProsdocimiLuigi Leanza

Abstract

Cancer is the consequence of aberrations in cell growth or cell death. In this scenario, mitochondria and ion channels play a critical role in regard to cell proliferation, malignant angiogenesis, migration, and metastasis. In this review, we focus on Kv1.3 and specifically on mitoKv1.3, which showed an aberrant expression in cancer cells compared with healthy tissues and which is involved in the apoptotic pathway. In recent years, mitoKv1.3 has become an oncological target since its pharmacological modulation has been demonstrated to reduce tumor growth and progression both in vitro and in vivo using preclinical mouse models of different types of tumors.

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Citations

Sep 21, 2019·SLAS Discovery·Mariafrancesca Scalise, Veli-Pekka Jaakola
Aug 1, 2020·Frontiers in Pharmacology·Andrei M GigolaevAlexander A Vassilevski
May 2, 2021·Medicinal Research Reviews·Špela GubičLucija P Mašič
Jul 25, 2021·International Journal of Molecular Sciences·Xuan WangJunjie Luo

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Methods Mentioned

BETA
co-immunoprecipitation
FRET
immunoprecipitations

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