PMID: 26343112Sep 8, 2015Paper

Targeting the NF-κB pathway in prostate cancer: a promising therapeutic approach?

Current Drug Targets
Daniela VerzellaFrancesca Zazzeroni

Abstract

Rel/NF-κB transcription factors are key regulators of genes implicated in inflammatory and immune activation, cell growth and protection from apoptosis. Constitutive activation of NF-κB has been observed in several types of cancers. Recently, it has been shown that inflammation and cancer are molecularly linked by means of NF-κB. During prostate cancer progression, NF-κB promotes cell survival, tumor invasion, metastasis and chemoresistance. NF-κB constitutive activation has been frequently demonstrated in primary prostate cancers and it correlates with loss of androgen receptor expression and castration-resistant phenotypes. Indeed, inhibition of NF-κB pathway may reduce the oncogenic effects mediated by chronic inflammatory response. Therefore, NF-κB represents a hopeful target for the treatment of prostate cancer due to its role in oncogenesis and chemoresistance. Here, the current knowledge about the roles of NF-κB signaling pathway in prostate tumorigenesis is discussed, taking into consideration the potentiality and effectiveness of NF-κB inhibitors as therapeutic agents for prostate cancer.

Citations

Aug 23, 2017·Biomedicines·Federica BegalliGuido Franzoso
Sep 3, 2020·International Journal of Molecular Sciences·Kamila DomińskaAgnieszka Wanda Piastowska Ciesielska
Mar 14, 2019·Molecular Medicine Reports·Long XiaoNingnan Zhang
Apr 2, 2020·Cell Death & Disease·Daniela VerzellaFrancesca Zazzeroni
Oct 21, 2020·Cancers·Maddison ArcherNatasha Kyprianou
Apr 13, 2021·Frontiers in Physiology·Qianghua XiaYongjie Wei
Aug 20, 2021·Scientific Reports·Menka KhoobchandaniKattesh V Katti
Sep 11, 2021·Cell Biology International·Larissa J SanchesAlessandra L Cecchini

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