Targeting the noradrenergic system for gender-sensitive medication development for tobacco dependence

Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
Terril L VerplaetseSherry A McKee

Abstract

Tobacco use remains the leading cause of morbidity and mortality for both women and men in the United States, and women often experience poorer smoking cessation outcomes than men. Preliminary evidence suggests there are sex differences in medication effectiveness for smoking cessation. However, current medications do not take into account gender-sensitive treatment development and efficacy, underscoring the importance of this underdeveloped area of research. We reviewed preclinical and clinical evidence for gender differences in the inability to quit smoking by examining (a) the effect of increased negative affect and stress reactivity on smoking outcomes in women and (b) smoking for nicotine reinforcement in men. We also reviewed the current literature targeting the noradrenergic system as a novel gender-sensitive treatment strategy for tobacco dependence. We hypothesize that noradrenergic agents that normalize noradrenergic activity may differentially attenuate stress reactivity in women and nicotine-related reinforcement in men, indicating that targeting the noradrenergic system for smoking cessation may be effective for both genders, with benefits operating through sex-specific mechanisms. Converging lines of preclinical a...Continue Reading

References

Sep 1, 1978·Pharmacology, Biochemistry, and Behavior·W M DavisT E Werner
Sep 16, 1976·Nature·A M ThierryJ Glowinski
Aug 1, 1991·British Journal of Addiction·L S Covey, A H Glassman
Jan 1, 1990·Pharmacology & Toxicology·D S Janowsky, D H Overstreet
May 1, 1989·British Journal of Addiction·J Grenhoff, T H Svensson
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·G B Glavin
Jan 1, 1986·Psychopharmacology·K A PerkinsR Stiller
Nov 16, 1984·Science·A H GlassmanB Rosenfeld
Jan 1, 1984·Psychopharmacology·R J WestB Kadam
Jan 1, 1980·Journal of Neural Transmission·G Engberg, T H Svensson
Sep 1, 1995·Journal of the American Academy of Child and Adolescent Psychiatry·P B ChappellD J Cohen
Nov 1, 1994·Naunyn-Schmiedeberg's Archives of Pharmacology·A U TrendelenburgN Limberger
Mar 16, 1993·European Journal of Pharmacology·J Grenhoff, T H Svensson
Jan 1, 1993·Neuroscience and Biobehavioral Reviews·D H Overstreet
Jan 1, 1996·Annual Review of Neuroscience·R A Wise
Jun 1, 1997·Journal of the American College of Cardiology·N L Benowitz, S G Gourlay
Apr 29, 1998·Archives of General Psychiatry·A F Arnsten, P S Goldman-Rakic
Aug 26, 1998·Archives of General Psychiatry·S M HallE Triffleman
Aug 18, 1999·Journal of Consulting and Clinical Psychology·B HitsmanW Xu
Aug 18, 1999·Journal of Consulting and Clinical Psychology·D W WetterT B Baker
Jul 7, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S ErbJ Stewart
Sep 15, 2000·Journal of the American Academy of Child and Adolescent Psychiatry·A F Arnsten
Nov 10, 2000·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·K A PerkinsA R Caggiula
Jun 14, 2001·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·K A PerkinsS Hutchison
Jul 31, 2001·CNS Drugs·K A Perkins
Sep 26, 2001·Archives of General Psychiatry·V KlimekG A Ordway
May 23, 2002·Experimental and Clinical Psychopharmacology·Jenny L WileyM Imad Damaj
Jul 26, 2002·Molecular Psychiatry·R D ShytleP R Sanberg
Aug 31, 2002·Psychopharmacology·Kenneth A PerkinsAnthony R Caggiula
Aug 31, 2002·Psychopharmacology·Elisabeth J HoutsmullerMaxine L Stitzer
Oct 9, 2002·Archives of General Psychiatry·Sharon M HallRoland Maude-Griffin
Oct 29, 2002·Psychopharmacology·Yavin ShahamJane Stewart
Jan 28, 2003·Biological Psychiatry·Tony P GeorgeStephanie S O'Malley
Apr 2, 2003·Brain Research. Brain Research Reviews·Craig W Berridge, Barry D Waterhouse

❮ Previous
Next ❯

Citations

Sep 29, 2015·Current Treatment Options in Psychiatry·Kathryn PolakDace S Svikis
Sep 11, 2016·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Philip H SmithSherry A McKee
Nov 1, 2016·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Amanda R MathewMatthew J Carpenter
Apr 26, 2017·Journal of Psychopharmacology·Terril L VerplaetseSherry A McKee
Feb 24, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yann S MineurMarina R Picciotto
Feb 11, 2020·Annual Review of Clinical Psychology·Gaylen E FronkJohn J Curtin
Aug 20, 2016·Journal of Psychoactive Drugs·Jamie L SimpsonRick A Bevins
Oct 4, 2020·Addictive Behaviors·William Magee, Philippa Clarke
Mar 1, 2019·Molecular Neuropsychiatry·Heath D SchmidtNii A Addy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.