Targeting the Notch signaling pathway in cancer therapeutics

Thoracic Cancer
Huajiao GuoJian Zhang

Abstract

Despite advances in surgery, imaging, chemotherapy, and radiotherapy, the poor overall cancer-related death rate remains unacceptable. Novel therapeutic strategies are desperately needed. Nowadays, targeted therapy has become the most promising therapy and a welcome asset to the cancer therapeutic arena. There is a large body of evidence demonstrating that the Notch signaling pathway is critically involved in the pathobiology of a variety of malignancies. In this review, we provide an overview of emerging data, highlight the mechanism of the Notch signaling pathway in the development of a wide range of cancers, and summarize recent progress in therapeutic targeting of the Notch signaling pathway.

References

Dec 4, 1992·Annals of the New York Academy of Sciences·V EllisK Danø
Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S Artavanis-TsakonasB Yedvobnick
Sep 28, 1995·Nature·S JarriaultA Israel
Oct 21, 1994·Cell·M E Fortini, S Artavanis-Tsakonas
May 30, 1997·The Journal of Biological Chemistry·Y ChenG N Gill
Jan 1, 1997·Molecular and Cellular Neurosciences·G Weinmaster
May 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H PappotJ Grøndahl-Hansen
Feb 7, 1998·Genes & Development·K M Cadigan, R Nusse
Apr 7, 1998·Molecular and Cellular Biology·F OswaldR M Schmid
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·F LogeatA Israël
Aug 26, 1998·The Biochemical Journal·P C HeinrichL Graeve
Jan 6, 1999·Proceedings of the National Academy of Sciences of the United States of America·J J HsiehS D Hayward
Apr 16, 1999·The EMBO Journal·T OhtsukaR Kageyama
Apr 30, 1999·Science·S Artavanis-TsakonasR J Lake
Oct 21, 1999·Journal of Cellular Physiology·L Miele, B Osborne
Nov 11, 1999·Oncogene·A DiévartP Jolicoeur
Nov 2, 2001·Nature·T ReyaI L Weissman
Dec 21, 2002·International Journal of Cancer. Journal International Du Cancer·Roberto SalgadoLuc Y Dirix
Jan 28, 2003·Journal of Cellular Physiology·Tatsuya IsoYasuo Hamamori
Feb 19, 2003·Nature Genetics·Michael NicolasFreddy Radtke
Mar 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Muhammad Al-HajjMichael F Clarke
Mar 15, 2003·Nature Reviews. Cancer·Erik Sahai, Christopher J Marshall
Sep 2, 2003·The Journal of Biological Chemistry·George H SearfossTimothy P Ryan
Oct 24, 2003·Nature·L M CalviD T Scadden
Feb 3, 2004·Current Pharmaceutical Design·Michael J Duffy
Oct 20, 2004·The Journal of Cell Biology·Salvatore PecePier Paolo Di Fiore
Nov 3, 2004·Cancer Research·Xing FanCharles G Eberhart
Nov 17, 2004·Genes & Development·Juan GalceranRudolf Grosschedl

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Citations

Oct 28, 2019·Anti-cancer Agents in Medicinal Chemistry·Priyanka VermaIndrakant K Singh
Jan 16, 2020·Journal of Cancer Research and Therapeutics·Haibo CaiYi Shen
Jan 16, 2020·Current Pharmaceutical Design·Sabah NisarAjaz A Bhat
Nov 7, 2017·European Surgery : ACA : Acta Chirurgica Austriaca·Marlena Brzozowa-ZasadaRomuald Wojnicz
Jan 10, 2019·Therapeutic Advances in Medical Oncology·Nuozhou WangGeorge G Chen

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