Targeting the palm: a leap forward toward treatment of keratin disorders

The Journal of Investigative Dermatology
Wera RothThomas M Magin

Abstract

Any rational therapy benefits from an understanding of basic biology and the simplicity of its strategy. Among keratinopathies, epidermolytic palmoplantar keratoderma stands out by virtue of hotspot mutations in the KRT9 gene, exclusively expressed in the palmoplantar epidermis. In this issue, Leslie Pedrioli et al. report on the successful application of KRT9-specific siRNAs in cultured cells and in a mouse model. The study beautifully illustrates the potency of a thorough experimental approach and the challenges that remain, especially in its delivery.

References

Oct 24, 1998·The Journal of Cell Biology·E HuttonE Fuchs
Nov 26, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Sancy A LeachmanRoger L Kaspar
Apr 19, 2011·Nature Reviews. Genetics·Beverly L Davidson, Paul B McCray
Apr 26, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Barbara GeusensJo Lambert
Jan 27, 2012·The Journal of Investigative Dermatology·Pierre A Coulombe, Chang-Hun Lee
Mar 10, 2012·The Journal of Investigative Dermatology·Deena M Leslie PedrioliW H Irwin McLean

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Citations

May 22, 2013·The Journal of Cell Biology·Cornelia KrögerThomas M Magin
May 12, 2015·The Journal of Investigative Dermatology·Melanie HombergThomas M Magin

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