Targeting the Post-Irradiation Tumor Microenvironment in Glioblastoma via Inhibition of CXCL12

Cancers
Frank A GiordanoCarsten Herskind

Abstract

Radiotherapy is a mainstay in glioblastoma therapy as it not only directly targets tumor cells but also depletes the tumor microvasculature. The resulting intra-tumoral hypoxia initiates a chain of events that ultimately leads to re-vascularization, immunosuppression and, ultimately, tumor-regrowth. The key component of this cascade is overexpression of the CXC-motive chemokine ligand 12 (CXCL12), formerly known as stromal-cell derived factor 1 (SDF-1). We here review the role of CXCL12 in recruitment of pro-vasculogenic and immunosuppressive cells and give an overview on future and current drugs that target this axis.

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Aug 3, 2019·Cancers·Ghazaleh Tabatabai, Hiroaki Wakimoto
Feb 18, 2021·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Vashendriya V V HiraCornelis J F Van Noorden

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Methods Mentioned

BETA
surgical resection
xenograft

Clinical Trials Mentioned

NCT01977677
NCT03168139

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