Targeting the prostate-specific membrane antigen for prostate cancer therapy

Immunotherapy
P BühlerU Elsässer-Beile

Abstract

Prostate cancer remains a leading cause of death for men in Western civilization. Despite the effectiveness of surgical prostatectomy, radiotherapy and hormonal therapy, a significant proportion of patients progress to advanced metastatic disease for which there are currently no curative treatment options. Therefore, new therapeutic approaches need to be considered. The prostate-specific membrane antigen is a cell-surface glycoprotein that is highly and specifically expressed on prostate epithelial cells and strongly upregulated in prostate cancer at all stages. These characteristics make it an attractive target for antibody-based imaging and therapies and the first anti-prostate-specific membrane antigen agents have already entered clinical trials. The proposed strategies include targeted toxins and radiotherapeutics as well as immunotherapeutic agents and vaccines.

References

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Citations

Aug 20, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Thomas EbenhanMike Sathekge
Jan 31, 2014·The British Journal of Surgery·D FuksO Farges
Mar 14, 2013·BioMed Research International·Daryoush Shahbazi-GahroueiCordula Gruettner

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Methods Mentioned

BETA
xenograft
PCR
xenografts
phage display

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