Targeting the RET pathway in thyroid cancer

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Samuel A Wells, Massimo Santoro

Abstract

The RET (rearranged during transfection) protooncogene encodes a single pass transmembrane receptor that is expressed in cells derived from the neural crest and the urogenital tract. As part of a cell-surface complex, RET binds glial derived neurotrophic factor (GDNF) ligands in conjunction with GDNF-family alpha co-receptors (GFRalpha). Ligand-induced activation induces dimerization and tyrosine phosphorylation of the RET receptor with downstream activation of several signal transduction pathways. Activating germline RET mutations play a central role in the development of the multiple endocrine neoplasia (MEN) syndromes MEN2A, MEN2B, and familial medullary thyroid carcinoma (FMTC) and also in the development of the congenital abnormality Hirschsprung's disease. Approximately 50% of patients with sporadic MTC have somatic RET mutations, and a significant portion of papillary thyroid carcinomas result from chromosomal inversions or translocations, which activate RET (RET/PTC oncogenes). The RET protooncogene has a significant place in cancer prevention and treatment. Timely thyroidectomy in kindred members who have inherited a mutated RET allele, characteristic of MEN2A, MEN2B, or FMTC, can prevent MTC, the most common cause of ...Continue Reading

Citations

Jan 19, 2013·Apoptosis : an International Journal on Programmed Cell Death·Minakshi MazumdarTanya Das
Feb 14, 2012·Nature Medicine·Takashi KohnoTatsuhiro Shibata
Aug 25, 2011·Nature Reviews. Endocrinology·Steven G WaguespackGilbert J Cote
Feb 15, 2013·The New England Journal of Medicine·Lori J WirthPeter M Sadow
Jul 5, 2013·Thyroid : Official Journal of the American Thyroid Association·Sophie BroutinJean-Michel Bidart
May 27, 2010·Briefings in Bioinformatics·Thomas Werner
Nov 30, 2011·Current Opinion in Oncology·Constantine TheoharisJulie Ann Sosa
Feb 22, 2012·Current Opinion in Oncology·Madson Q Almeida, Ana O Hoff
Jul 23, 2011·Genes & Cancer·Alberto Fernández-Medarde, Eugenio Santos
Feb 13, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Geoffrey R OxnardPasi A Jänne
Jun 9, 2010·The Journal of Clinical Endocrinology and Metabolism·James A FaginDavid G Pfister
Nov 24, 2011·Endocrine-related Cancer·Yoon Woo KohMatthew D Ringel
Jul 7, 2010·Endocrine-related Cancer·Maya B Lodish, Constantine A Stratakis
Nov 22, 2013·Thyroid : Official Journal of the American Thyroid Association·Sophie BroutinJean-Michel Bidart
May 21, 2013·Experimental and Molecular Pathology·Jena HudsonRebecca D Chernock
Jun 22, 2014·Journal of Endocrinological Investigation·M PucciniP Buccianti
Oct 25, 2012·Case Reports in Medicine·Banafshe ShahnazariAbdolreza Babamahmoodi
Jul 3, 2013·The Oncologist·Justin F Gainor, Alice T Shaw
Feb 24, 2016·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Atsushi HoriikeMakoto Nishio
Aug 13, 2013·Expert Opinion on Biological Therapy·Gabriele MinutiFederico Cappuzzo
Nov 26, 2015·Molecular Diagnosis & Therapy·Zahra Nozhat, Mehdi Hedayati
Mar 19, 2014·Current Problems in Surgery·Richard HodinAntonia Stephen
Jul 5, 2011·Bioorganic & Medicinal Chemistry Letters·Kuei-Chung ShihJui-Wen Huang
Oct 19, 2010·Cancer Genetics and Cytogenetics·Madson Q Almeida, Constantine A Stratakis
Nov 28, 2015·Archivum Immunologiae Et Therapiae Experimentalis·Nan Xiao, Quynh-Thu Le
Jun 17, 2015·Revue des maladies respiratoires·D RouviereJ Mazieres
May 11, 2011·Journal of Surgical Oncology·Ryo TanakaDave S B Hoon
Jun 20, 2014·Cancer·Jessica E MaxwellJames R Howe
Sep 14, 2015·Surgical Oncology Clinics of North America·Jeffrey A NortonRobert T Jensen
Jul 22, 2014·Journal of Surgical Oncology·Emily A Stevens, Cristina P Rodriguez
Jun 18, 2010·Clinical Oncology : a Journal of the Royal College of Radiologists·C ChougnetM Schlumberger
Apr 27, 2012·Neurobiology of Aging·Diana ScholzMarcel Leist
Dec 17, 2014·Frontiers in Oncology·Alona Zer, Natasha Leighl

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