Targeting the retroviral ribonuclease H by rational drug design

AIDS
Karin Moelling

Abstract

Ribonucleases H or RNases H are conserved and exist in almost every organism. They generate and remove RNA primers, which are required for DNA replication. RNases H hydrolyze RNA in RNA-DNA hybrids. RNases H and related enzymes contribute to reduction of gene expression in antisense and small-interfering RNA mechanisms for gene silencing. Retroviruses code for RNases H, which are required for DNA provirus synthesis. Their RNase H is fused to the reverse transcriptase and essential for virus replication inside the cell. Retroviruses code for four enzymes, three of which have been targeted by antiretroviral therapies. A drug against the fourth one, the retroviral RNase H, does not yet exist. The viral but not cellular RNases H should be targeted by drug design. Some details will be discussed here. Furthermore, a compound is described, which enables the RNase H to kill cell-free HIV particles by driving the virus into suicide - with potential use as a microbicide.

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Citations

Apr 10, 2013·Archives of Virology·Karin Moelling
May 9, 2013·Sexual Health·Bidhubhusan MahapatraMichel Alary
Aug 31, 2012·AIDS Research and Human Retroviruses·Felix BroeckerKarin Moelling
Nov 14, 2013·Sexually Transmitted Diseases·Ariane van der StratenMark H Einstein
Apr 17, 2012·Sexually Transmitted Diseases·Jason W Mitchell, Andrew E Petroll
Dec 20, 2012·Sexually Transmitted Diseases·Steven M Goodreau
Dec 24, 2013·AIDS·Anisa GhadrshenasUNKNOWN Child Survival Working Group of the Interagency Task Team on the Prevention and Treatment of HIV infection in Pregnant Women
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Jul 13, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Thomas A OdenyR Scott McClelland
Jan 29, 2014·AIDS·Sharmistha MishraUNKNOWN Strategic Epi-ART in India Modelling Team
Jan 22, 2014·Current Opinion in HIV and AIDS·Stefan D BaralErin Papworth
Dec 11, 2013·Current Opinion in HIV and AIDS·Tonia PoteatAnita Radix
Feb 14, 2014·Sexually Transmitted Diseases·Hong-Van TieuUNKNOWN NYC M2M Study Team
Nov 14, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Priscilla MartinezPeter W Hunt
Sep 10, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Sharon B MannheimerKenneth H Mayer
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Jun 25, 2014·AIDS·Kimberly A Powers, Myron S Cohen
Feb 24, 2015·Annals of the New York Academy of Sciences·Karin Moelling, Felix Broecker
Sep 16, 2020·Biosensors & Bioelectronics·Asiyeh JebelliMiguel de la Guardia

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