Targeting the "species gene ensemble"

Hippocampus
Aryeh Routtenberg

Abstract

The members of a given species display a normal distribution of gene expression which is here termed the species gene ensemble. This more specific designation of the 'genetic background' leads to a consideration of why gene targeting outcomes are regulated by the species gene ensemble. One consequence is the utility of the heterozygous knockout which buffers the drastic compensatory reactions of the homozygous knockout thereby revealing subtle but yet consistent alterations in hippocampally-dependent behaviors.

References

Mar 23, 1995·Nature·A Routtenberg
Mar 4, 1996·The Journal of Comparative Neurology·I Cantallops, A Routtenberg
Feb 1, 1997·Trends in Neurosciences·L I Benowitz, A Routtenberg
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·P E Schauwecker, O Steward
Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·U NamgungA Routtenberg
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Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·A RouttenbergU Namgung
Apr 20, 2001·Trends in Neurosciences·H Husi, S G Grant
Jun 27, 2001·Nature Neuroscience
Jul 19, 2001·Nature

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Citations

Feb 10, 2004·Proceedings of the National Academy of Sciences of the United States of America·Richard PietStéphane H R Oliet
May 10, 2006·Genes, Brain, and Behavior·N SousaC T Wotjak
Jun 1, 2006·Genes, Brain, and Behavior·P J JaubertR F Berman
Aug 6, 2010·Journal of Lipid Research·Mireille BasselinStanley I Rapoport
Sep 25, 2004·Hippocampus·Jerome L RekartAryeh Routtenberg

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