PMID: 25731686Mar 4, 2015Paper

Targeting the spindle assembly checkpoint for breast cancer treatment

Current Cancer Drug Targets
Sandra MarquesHassan Bousbaa

Abstract

Breast cancer is the most common malignancy in women worldwide and the second leading cause of cancer deaths after lung cancer. As in other malignancies, aneuploidy is a common feature of breast cancer and influences its behavior. Aneuploidy has been linked to inappropriate activity of the spindle assembly checkpoint (SAC), a surveillance mechanism that, in normal cells, prevents anaphase onset until correct alignment of all chromosomes at the metaphase is achieved. Interestingly, the widely used anti-microtubule drugs, vinca alkaloids and taxanes, kill cancer cells through chronic arrest in mitosis as a consequence of chronic SAC activation. Deregulated SAC has been reported in breast cancer in many reports and presents an attractive therapeutic strategy. We present here a review of the current knowledge on the SAC defects and the underlying molecular mechanisms in breast cancer, and discuss the potential of SAC components as targets for breast cancer therapies.

Citations

Aug 15, 2018·Molecular Systems Biology·Lorenz J MaierChristian Conrad
May 28, 2019·Journal of Cellular Physiology·Qiang MaXiaolan Guo
Nov 23, 2017·Mathematical Biosciences and Engineering : MBE·Bashar Ibrahim
Feb 29, 2020·Journal of Family Medicine and Primary Care·Sulaiman Abdullah AlshammariAbdullah Mohammed Alshahrani
Jun 22, 2017·Scientific Reports·Richard HenzeBashar Ibrahim

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