Targeting the stromal androgen receptor in primary prostate tumors at earlier stages.

Proceedings of the National Academy of Sciences of the United States of America
Yuanjie NiuChawnshang Chang

Abstract

To differentiate roles of androgen receptor (AR) in prostate stromal and epithelial cells, we have generated inducible-(ind)ARKO-TRAMP and prostate epithelial-specific ARKO TRAMP (pes-ARKO-TRAMP) mouse models, in which the AR was knocked down in both prostate epithelium and stroma or was knocked out in the prostate epithelium, respectively. We found that loss of AR in both mouse models resulted in poorly differentiated primary tumors with expanded intermediate cell populations. Interestingly, knockdown of both epithelial and stromal AR in ind-ARKO-TRAMP mice at earlier stages resulted in smaller primary prostate tumors with lower proliferation rates, and knockout of AR in pes-ARKO-TRAMP mice resulted in larger primary prostate tumors with higher proliferation rates. The differential proliferation rates, yet with similarly expanded intermediate cell populations, indicated that the prostate stromal AR might play a more dominant role than the epithelial AR to promote primary tumor proliferation at an early stage of tumor. Tissue recombination of human prostate stromal cell lines (WPMY1-v or WPMY1-ARsi) with human prostate cancer epithelial cell lines (PC3-v or PC3-AR9) further demonstrated that the AR might function as a suppresso...Continue Reading

References

Jan 1, 1976·International Review of Cytology·G R Cunha
Jul 1, 1988·Developmental Biology·A A Donjacour, G R Cunha
Aug 11, 1998·Differentiation; Research in Biological Diversity·S W HaywardG R Cunha
Oct 8, 1998·The New England Journal of Medicine·M A EisenbergerB A Lowe
Dec 18, 2001·The Journal of Pathology·G J van LeendersJ A Schalken
Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Shuyuan YehMin-Chi Hung
Jan 2, 2004·Nature Medicine·Charlie D ChenCharles L Sawyers
Apr 15, 2004·Endocrine Reviews·Cynthia A Heinlein, Chawnshang Chang
Oct 29, 2004·The American Journal of Pathology·Alvin Y LiuLawrence D True
May 10, 2005·The Journal of Urology·Ginger Isom-BatzJames A Eastham
Apr 5, 2007·Journal of the National Cancer Institute·Hiroshi MiyamotoChawnshang Chang
Jul 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·Chun-Te WuChawnshang Chang
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Yuanjie NiuChawnshang Chang

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Citations

Apr 9, 2009·Nature Reviews. Urology·Anne T Collins, Norman J Maitland
Sep 8, 2010·Nature Reviews. Urology·Maria KarlouEleni Efstathiou
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Yuanjie NiuChawnshang Chang
Apr 27, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sanaz MemarzadehOwen N Witte
May 18, 2012·Japanese Journal of Clinical Oncology·Yi LiHiroshi Miyamoto
Nov 11, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Meng-Lei Zhu, Natasha Kyprianou
Sep 17, 2010·Genes & Development·Michael M Shen, Cory Abate-Shen
Mar 2, 2011·PloS One·Gabriella CastoriaFerdinando Auricchio
Apr 13, 2013·Endocrine-related Cancer·Xinyu WuZoran Culig
Jul 19, 2013·Pharmacology & Therapeutics·Ayesha A ShafiNancy L Weigel
Feb 8, 2011·Journal of Endocrinological Investigation·G CoronaM Maggi
May 30, 2014·Endocrine-related Cancer·Cera M NietoScott D Cramer
Nov 20, 2012·Annual Review of Physiology·Takahiro MatsumotoShigeaki Kato
Feb 18, 2016·Stem Cells International·Alastair H Davies, Amina Zoubeidi
Dec 8, 2011·The Journal of Steroid Biochemistry and Molecular Biology·Keely M McNamaraUlla Simanainen
Apr 20, 2014·International Journal of Endocrinology·Mauro GacciSergio Serni
Aug 5, 2014·The American Journal of Pathology·Mandeep SinghPeng Lee
Sep 15, 2012·The Prostate·Keely M McNamaraUlla Simanainen
Mar 25, 2011·The Prostate·Paul A BerryAnne T Collins
Jan 28, 2015·Molecular Cancer·Diego Iglesias-GatoAmilcar Flores-Morales
May 3, 2014·Seminars in Oncology·Paola ChiarugiPaolo Cirri

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