Targeting the turnover of oncoproteins as a new avenue for therapeutics development in castration-resistant prostate cancer

Cancer Letters
Shan WangRalf Kittler

Abstract

The current therapeutic armamentarium for castration-resistant prostate cancer (CRPC) includes second-generation agents such as the Androgen Receptor (AR) inhibitor enzalutamide and the androgen synthesis inhibitor abiraterone acetate, immunotherapies like sipuleucel-T, chemotherapies including docetaxel and cabazitaxel and the radiopharmaceutical radium 223 dichloride. However, relapse of CRPC resistant to these therapeutic modalities occur rapidly. The mechanisms of resistance to these treatments are complex, including specific mutations or alternative splicing of oncogenic proteins. An alternative approach to treating CRPC may be to target the turnover of these molecular drivers of CRPC. In this review, the mechanisms by which protein stability of several oncoproteins such as AR, ERG, GR, CYP17A1 and MYC, will be discussed, as well as how these findings could be translated into novel therapeutic agents.

References

Sep 28, 2000·Biochemical and Biophysical Research Communications·L SheflinS W Spaulding
Sep 14, 2001·The Journal of Biological Chemistry·A D Wallace, J A Cidlowski
Oct 24, 2001·The Journal of Biological Chemistry·Hiroshi MiyamotoChawnshang Chang
May 25, 2002·Molecular and Cellular Biology·Bonnie J DerooTrevor K Archer
May 29, 2003·Molecular Cell·So Young KimWilliam P Tansey
Jan 6, 2004·Science·Lyubomir T VassilevEmily A Liu
Feb 13, 2004·Developmental Cell·Tommaso NastasiAlessandra D'Azzo
Apr 23, 2004·The EMBO Journal·Masayoshi YadaKeiichi I Nakayama
May 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·Markus WelckerBruce E Clurman
Dec 22, 2005·Molecular and Cellular Endocrinology·Hortensia FausBernard Haendler
Jul 19, 2006·Cellular & Molecular Biology Letters·Tomasz Jaworski
Apr 19, 2007·The Prostate·Ian R LoganCraig N Robson
Jun 15, 2007·Nature Cell Biology·Nikita PopovMartin Eilers
Sep 18, 2007·Cell Cycle·Nikita PopovMartin Eilers
Dec 18, 2007·Neoplasia : an International Journal for Oncology Research·Fatouma AlimirahDivaker Choubey
Feb 28, 2008·The Cancer Journal·Li Shen, Roberto Pili
Aug 16, 2008·The Journal of Biological Chemistry·Hongyun LiShiv Srivastava

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