Targeting the (Un)differentiated State of Cancer

Cancer Cell
Lajos V Kemeny, David E Fisher

Abstract

Dedifferentation in cancer is associated with intrinsic and acquired resistance to therapies. In this issue of Cancer Cell, Tsoi et al. identify four differentiation states in melanoma and provide evidence that melanoma cells develop drug resistance through a stepwise dedifferentiation process, making them vulnerable to ferroptotic cell death-inducing compounds.

Citations

Nov 11, 2020·International Journal of Molecular Sciences·Karol GranadosJochen Utikal

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