Targeting the Viral Polymerase of Diarrhea-Causing Viruses as a Strategy to Develop a Single Broad-Spectrum Antiviral Therapy

Viruses
Marcella BassettoJoana Rocha-Pereira

Abstract

Viral gastroenteritis is an important cause of morbidity and mortality worldwide, being particularly severe for children under the age of five. The most common viral agents of gastroenteritis are noroviruses, rotaviruses, sapoviruses, astroviruses and adenoviruses, however, no specific antiviral treatment exists today against any of these pathogens. We here discuss the feasibility of developing a broad-spectrum antiviral treatment against these diarrhea-causing viruses. This review focuses on the viral polymerase as an antiviral target, as this is the most conserved viral protein among the diverse viral families to which these viruses belong to. We describe the functional and structural similarities of the different viral polymerases, the antiviral effect of reported polymerase inhibitors and highlight common features that might be exploited in an attempt of designing such pan-polymerase inhibitor.

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Citations

Aug 25, 2020·Current Opinion in Infectious Diseases·Anna FunkStephen B Freedman
Jul 28, 2019·Proceedings of the National Academy of Sciences of the United States of America·Yao HeZ Hong Zhou
Dec 31, 2020·International Journal of Molecular Sciences·Oluwakemi EbenezerMichael Shapi
May 13, 2021·MBio·María Julieta Tohmé, Laura Ruth Delgui
Jul 1, 2021·Antiviral Chemistry & Chemotherapy·Jana Van DyckeJoana Rocha-Pereira
Aug 28, 2021·Microorganisms·Nanci Santos-FerreiraJoana Rocha-Pereira

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Software Mentioned

DELTA
Clustal Omega
BLAST

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