Targeting therapy for inflammatory diseases by anti-TNFalpha biologics

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Takahisa Sugita

Abstract

TNFalpha (tumor necrosis factor-alpha) plays a critical role in the pathogenesis of inflammatory diseases including rheumatoid arthritis and Crohn's disease. Infliximab is a monoclonal antibody that recognizes human TNFalpha. Clinical trials have been persuasive that infliximab is effective and far superior to the conventional drug therapy in various inflammatory diseases. Combination of infliximab plus methotrexate is effective in patients with active rheumatoid arthritis who have not responded adequately to traditional disease-modifying anti-rheumatic drugs, and has produced significant improvement in clinical, radiographic, and functional outcomes. Infliximab is also an important treatment option in patients with active Crohn's disease who have not responded to conventional therapy and in those with this disease who have fistulae. Moreover, infliximab treatment has resulted in effective suppression of ankylosing spondylitis, psoriasis and ocular inflammation in patients with refractory uveoretinitis due to Behçet's disease. Thus, biologics targeting TNFalpha have revolutionized the therapy of inflammatory diseases. Here, the current status of clinical application of anti-TNFalpha biologics is reviewed by describing the clini...Continue Reading

References

Apr 1, 1994·Clinical and Experimental Immunology·P EttehadiR D Camp
Nov 30, 2000·The New England Journal of Medicine·P E LipskyUNKNOWN Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group
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Feb 5, 2005·Arthritis and Rheumatism·Désirée van der HeijdeUNKNOWN Ankylosing Spondylitis Study for the Evaluation of Recombinant Infliximab Therapy Study Group

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Citations

Sep 4, 2012·Archives of Pharmacal Research·Weon-Jong YoonEun-Sook Yoo
Nov 24, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Min-Ji BakWoo-Sik Jeong
Oct 28, 2019·Immunological Medicine·Kazuichi Maruyama
Nov 2, 2013·International Journal of Molecular Sciences·Yu-Jin HwangKyung-A Hwang

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