Targeting Therapy Resistance: When Glutamine Catabolism Becomes Essential

Cancer Cell
Michael J LukeyRichard A Cerione

Abstract

Identifying contexts in which cancer cells become addicted to specific nutrients is critical for developing targeted metabolic therapies. In this issue of Cancer Cell, Momcilovic et al. report that suppressed glycolysis following mTOR inhibition is countered by adaptive glutamine catabolism in lung squamous cell carcinoma, sensitizing tumors to glutaminase inhibition.

Citations

Jul 29, 2020·The EMBO Journal·Shih-Jung FanDeborah Ci Goberdhan
Jul 3, 2019·Journal of Cell Science·Arash LatifkarMarc A Antonyak
Jul 2, 2021·Journal of Cell Communication and Signaling·Fei LiuShuo Li

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