Targeting TMPRSS2 in SARS-CoV-2 Infection

Mayo Clinic Proceedings
Linda B BaughnRafael Fonseca

Abstract

Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has rapidly caused a global pandemic associated with a novel respiratory infection: coronavirus disease-19 (COVID-19). Angiotensin-converting enzyme-2 (ACE2) is necessary to facilitate SARS-CoV-2 infection, but-owing to its essential metabolic roles-it may be difficult to target it in therapies. Transmembrane protease serine 2 (TMPRSS2), which interacts with ACE2, may be a better candidate for targeted therapies. Using publicly available expression data, we show that both ACE2 and TMPRSS2 are expressed in many host tissues, including lung. The highest expression of ACE2 is found in the testes, whereas the prostate displays the highest expression of TMPRSS2. Given the increased severity of disease among older men with SARS-CoV-2 infection, we address the potential roles of ACE2 and TMPRSS2 in their contribution to the sex differences in severity of disease. We show that expression levels of ACE2 and TMPRSS2 are overall comparable between men and women in multiple tissues, suggesting that differences in the expression levels of TMPRSS2 and ACE2 in the lung and other non-sex-specific tissues may not explain the gender disparities in severity of SARS CoV-2. However, given...Continue Reading

References

Jun 21, 2002·Nature·Michael A CrackowerJosef M Penninger
Nov 9, 2004·Laboratory Investigation; a Journal of Technical Methods and Pathology·Junya GiboHajime Nawata
Jan 24, 2006·Molecular and Cellular Biology·Tom S KimPeter S Nelson
Jun 30, 2015·PloS One·Nadezda Kryuchkova-Mostacci, Marc Robinson-Rechavi
Jun 30, 2016·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Alaa Badawi, Seung Gwan Ryoo
Apr 5, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rudragouda ChannappanavarStanley Perlman
Oct 13, 2017·Nature·Taru TukiainenDaniel G MacArthur
Jan 25, 2020·The New England Journal of Medicine·Na ZhuUNKNOWN China Novel Coronavirus Investigating and Research Team
Jan 28, 2020·Lancet·Chen WangGeorge F Gao
Feb 8, 2020·JAMA : the Journal of the American Medical Association·Dawei WangZhiyong Peng
Feb 23, 2020·The Lancet Infectious Diseases·Ensheng DongLauren Gardner
Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19
Mar 14, 2020·Proceedings of the National Academy of Sciences of the United States of America·Shutoku MatsuyamaMakoto Takeda
Mar 20, 2020·Critical Care : the Official Journal of the Critical Care Forum·Yu ShiJifang Sheng
Apr 1, 2020·The New England Journal of Medicine·Muthiah VaduganathanScott D Solomon
Apr 4, 2020·American Journal of Respiratory and Critical Care Medicine·Yingzhen DuGuogang Xu
Apr 7, 2020·JAMA : the Journal of the American Medical Association·Giacomo GrasselliUNKNOWN COVID-19 Lombardy ICU Network
Apr 12, 2020·Cancer Discovery·Konrad H StopsackPhilip W Kantoff
Apr 19, 2020·The Lancet Infectious Diseases·Michael S XydakisClaire Hopkins
Apr 20, 2020·Journal of the American Academy of Dermatology·Angelo Valerio MarzanoPiergiacomo Calzavara-Pinton
Apr 30, 2020·Nature Reviews. Immunology·Matthew Zirui TayLisa F P Ng
May 16, 2020·Frontiers in Public Health·Jian-Min JinJin-Kui Yang

❮ Previous
Next ❯

Citations

Feb 12, 2021·International Journal of Environmental Research and Public Health·Iqra MehmoodMuhammad Tahir Ul Qamar
Feb 16, 2021·Frontiers in Cellular and Infection Microbiology·Elisavet StavropoulouEugenia Bezirtzoglou
Mar 2, 2021·Reviews in Medical Virology·Mustafa AlwaniRidwan Shabsigh
Nov 26, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Girish PathangeyAmr E Abbas
Oct 6, 2020·Mayo Clinic Proceedings·Tu HaitaoVesna D Garovic
Feb 28, 2021·Journal of Medical Virology·Asim Z AbbasiNasir Jalal
Apr 15, 2021·Journal of Medical Virology·Shibi MuralidarSenthil Visaga Ambi
May 18, 2021·Andrology·Edson BorgesDaniela Paes de Almeida Ferreira Braga
Jun 3, 2021·Journal of Clinical Medicine·Giuseppe CarotaGiovanni Li Volti
Nov 26, 2020·American Journal of Physiology. Endocrinology and Metabolism·Narasimhan KothandaramanMelvin Khee Shing Leow
Jul 3, 2021·International Journal of Environmental Research and Public Health·Luigi MontanoMarina Piscopo

❮ Previous
Next ❯

Datasets Mentioned

BETA
GSE66499

Clinical Trials Mentioned

NCT04321096
NCT04338906

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.