Targeting TOR dependence in cancer.

Oncotarget
Matthew R Janes, David A Fruman

Abstract

A challenge in cancer therapy has been to identify targets whose function is essential for survival of malignant cells but not normal cells. This Perspective discusses recent evidence that novel inhibitors of the kinase TOR can provide an unprecedented balance of anti-cancer efficacy and tolerability.

References

Feb 19, 2005·Science·D D SarbassovDavid M Sabatini
Feb 14, 2006·Cell·Stephan WullschlegerMichael N Hall
Apr 11, 2006·Molecular Cell·Dos D SarbassovDavid M Sabatini
Jul 19, 2006·Nature Reviews. Genetics·Jeffrey A EngelmanLewis C Cantley
Nov 28, 2006·Nature Immunology·Jianxun SongMichael Croft
Dec 8, 2006·The New England Journal of Medicine·Brian J DrukerUNKNOWN IRIS Investigators
Jul 7, 2007·Cancer Cell·David A Guertin, David M Sabatini
Nov 13, 2007·Biochimica Et Biophysica Acta·Romina MaroneMatthias P Wymann
Nov 22, 2007·PloS One·Kathrin ThedieckMichael N Hall
Jan 23, 2008·Expert Opinion on Therapeutic Targets·Robert T Abraham, Christina H Eng
Jul 8, 2008·Leukemia & Lymphoma·Amanda J Redig, Leonidas C Platanias
Aug 30, 2008·Current Opinion in Pharmacology·Timothy A YapPaul Workman
Sep 17, 2008·Oncogene·C Garcia-Echeverria, W R Sellers
Oct 29, 2008·Proceedings of the National Academy of Sciences of the United States of America·Andrew Y ChooJohn Blenis
Jan 20, 2009·The Journal of Biological Chemistry·Carson C ThoreenNathanael S Gray
Apr 2, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kathryn E O'ReillyIman Osman
Apr 14, 2009·Trends in Immunology·Thomas Weichhart, Marcus D Säemann
Apr 22, 2009·Targeted Oncology·Kamalesh SankhalaMonica Mita
Apr 25, 2009·Nature Reviews. Immunology·Angus W ThomsonGiorgio Raimondi
Jun 6, 2009·Proceedings of the National Academy of Sciences of the United States of America·Nadine CybulskiMichael N Hall
Jun 23, 2009·Nature·Koichi ArakiRafi Ahmed
Jul 4, 2009·Cancer Cell·Krishna M VasudevanLevi A Garraway
Jul 10, 2009·Molecular Immunology·Greg M DelgoffeJonathan D Powell
Sep 2, 2009·Molecular and Cellular Biology·Christian C DibbleBrendan D Manning
Oct 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·Anthony C FaberJeffrey A Engelman
Nov 11, 2009·Cell Cycle·Boris ShorKer Yu
Dec 10, 2009·Molecular and Cellular Biology·Louis-Andre JulienPhilippe P Roux
Jan 15, 2010·Nature Medicine·Matthew R JanesDavid A Fruman
Feb 25, 2010·Cancer Research·Paul WorkmanRob L M van Montfort
Feb 25, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Peter J Houghton

❮ Previous
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Citations

Apr 6, 2012·Breast Cancer Research and Treatment·Haiyan LiXiaochun Bai
Nov 12, 2014·Proceedings of the National Academy of Sciences of the United States of America·Jose J LimonDavid A Fruman
Feb 9, 2011·Expert Opinion on Investigational Drugs·Angelica Fasolo, Cristiana Sessa
Sep 1, 2011·American Journal of Physiology. Endocrinology and Metabolism·Yuria SaitoKazuhiro Takekoshi
Feb 18, 2012·Technology in Cancer Research & Treatment·Rekha PuriaVikrant Nain
Aug 21, 2013·Expert Opinion on Therapeutic Patents·Fei LiuRuo-Yun Tan
Feb 11, 2015·Expert Opinion on Drug Metabolism & Toxicology·Andrea GombosAhmad Awada
Apr 24, 2014·Apoptosis : an International Journal on Programmed Cell Death·Xin YuDarren R Carpizo
Jun 7, 2014·Frontiers in Oncology·Sarah K TasianSusan R Rheingold
Feb 1, 2014·Nature Reviews. Drug Discovery·David A Fruman, Christian Rommel
Jan 10, 2012·Aging·Zoya N Demidenko, James A McCubrey
Feb 28, 2014·Oncoimmunology·Mikhail V Blagosklonny
Mar 7, 2015·Nature Reviews. Drug Discovery·Mamatha BhatIvan Topisirovic
Dec 19, 2013·Cancer Biology & Therapy·Mikhail V Blagosklonny
Oct 12, 2012·Breast Cancer Research and Treatment·Yue ZhangXiaochun Bai
Mar 1, 2012·The Biochemical Journal·Lomon So, David A Fruman
Jan 17, 2012·Aging·Mikhail V Blagosklonny
Sep 10, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Collin Vu, David A Fruman

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Methods Mentioned

BETA
xenograft
xenografts

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