Targeting TRAF3 signaling protects against hepatic ischemia/reperfusions injury

Journal of Hepatology
Junfei HuHongliang Li

Abstract

The hallmarks of hepatic ischemia/reperfusion (I/R) injury, a common clinical problem that occurs during liver surgical procedures, include severe cell death and inflammatory responses that contribute to early graft failure and a higher incidence of organ rejection. Unfortunately, effective therapeutic strategies are limited. Tumor necrosis factor receptor (TNFR)-associated factor (TRAF) 3 transduces apoptosis and/or inflammation-related signaling pathways to regulate cell survival and cytokine production. However, the role of TRAF3 in hepatic I/R-induced liver damage remains unknown. Hepatocyte- or myeloid cell-specific TRAF3 knockdown or transgenic mice were subjected to an I/R model in vivo, and in vitro experiments were performed by treating primary hepatocytes from these mice with hypoxia/reoxygenation stimulation. The function of TRAF3 in I/R-induced liver damage and the potential underlying mechanisms were investigated through various phenotypic analyses and biological approaches. Hepatocyte-specific, but not myeloid cell-specific, TRAF3 deficiency reduced cell death, inflammatory cell infiltration, and cytokine production in both in vivo and in vitro hepatic I/R models, whereas hepatic TRAF3 overexpression resulted in t...Continue Reading

References

Sep 14, 2000·Proceedings of the National Academy of Sciences of the United States of America·C Z NiK R Ely
May 12, 2005·Journal of Hepatology·Tetsuya UeharaDavid A Brenner
Jan 24, 2006·Cell Death and Differentiation·N T GeorgopoulosL K Trejdosiewicz
Feb 1, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Harmeet MalhiJohn J Lemasters
May 15, 2007·Oncogene·A AdhikariZ J Chen
Jan 29, 2008·Biochemical and Biophysical Research Communications·Natsuko TanimuraKensuke Miyake
Jun 25, 2008·The Journal of Experimental Medicine·Minghui TangJiwang Zhang
Jun 11, 2011·Nature Reviews. Immunology·Hans HäckerMichael Karin
Jun 15, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Y ZhaiJ W Kupiec-Weglinski
Oct 28, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nozomu SakaiAlex B Lentsch
Mar 31, 2012·Transplantation Reviews·Hartmut Jaeschke, Benjamin L Woolbright
May 23, 2012·Cytokine & Growth Factor Reviews·Rowan F van GolenMichal Heger
Jul 21, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sibylle J RauRichard Fischer
Jul 26, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sandra PommeyKaren M Dwyer
May 15, 2013·Trends in Immunology·Adebusola A AjibadeRong-Fu Wang
Oct 15, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xin-An WangHongliang Li
Feb 28, 2014·Journal of the American Heart Association·Huei-Ping TzengDouglas L Mann
May 8, 2014·Journal of Molecular Histology·Ya WuXiaozu Xu
Aug 26, 2014·Journal of Hepatology·Pi-Xiao WangHongliang Li
Oct 17, 2014·Cell Death & Disease·X-F ZhangH Li
Jan 30, 2015·American Journal of Physiology. Endocrinology and Metabolism·Zheng ChenLiangyou Rui
Jan 30, 2015·Nature·UNKNOWN Cancer Genome Atlas Network

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Citations

Dec 17, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Feng-Juan YanHongliang Li
Oct 28, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Siyuan WangYi-Da Tang
May 10, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Peng SunYi-Da Tang
Aug 5, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ling YangXiaohua Hou
Apr 25, 2019·Journal of Cellular Biochemistry·Wenbo HuFei Li
May 12, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zhen-Zhen YanHongliang Li
Jan 1, 2020·PloS One·Valerie ZabalaJennifer A Sanders
Mar 13, 2018·Current Pharmacology Reports·Almin I LalaniPing Xie
Apr 16, 2020·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Junbin ZhouXiao Xu
Mar 11, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Wen-Ming PanJin-Xiang Zhang
Jul 8, 2020·Journal of the American Society of Nephrology : JASN·Sandra Rayego-MateosMarta Ruiz-Ortega
Jun 27, 2020·Journal of Cardiovascular Pharmacology·Guixiang ZhaoZhiqiang Liu
Nov 20, 2016·Transplantation·Ling LuYuan Zhai
Jul 19, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shimin AnYi-Da Tang
Nov 1, 2017·Cardiovascular Research·Yaxing ZhangHongliang Li
Dec 20, 2018·Physiological Reviews·Meng XuHongliang Li
Jun 11, 2019·Frontiers in Pharmacology·Kuei-Yi HungShi-Jye Chu
Dec 15, 2018·Journal of Cellular and Molecular Medicine·Wan-Jung LuRay-Jade Chen
Oct 11, 2019·Trends in Endocrinology and Metabolism : TEM·Ze ChenHongliang Li
Nov 24, 2020·Frontiers in Cell and Developmental Biology·Wei ZhouQifa Ye
Jan 8, 2021·International Journal of Molecular Sciences·Marcello DallioAlessandro Federico
Mar 12, 2020·Free Radical Biology & Medicine·Ze ChenHongliang Li
May 25, 2021·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Jun-Liang PuZhong-Jun Wu
Aug 10, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shufang LiBei Zhang
Jun 17, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Junjie ZhouPeng Zhang

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