Targeting transporters: Promoting blood-brain barrier repair in response to oxidative stress injury

Brain Research
Patrick T Ronaldson, Thomas P Davis

Abstract

The blood-brain barrier (BBB) is a physical and biochemical barrier that precisely regulates the ability of endogenous and exogenous substances to accumulate within brain tissue. It possesses structural and biochemical features (i.e., tight junction and adherens junction protein complexes, influx and efflux transporters) that work in concert to control solute permeation. Oxidative stress, a critical component of several diseases including cerebral hypoxia/ischemia and peripheral inflammatory pain, can cause considerable injury to the BBB and lead to significant CNS pathology. This suggests a critical need for novel therapeutic approaches that can protect the BBB in diseases with an oxidative stress component. Recent studies have identified molecular targets (i.e., putative membrane transporters, intracellular signaling systems) that can be exploited for optimization of endothelial drug delivery or for control of transport of endogenous substrates such as the antioxidant glutathione (GSH). In particular, targeting transporters offers a unique approach to protect BBB integrity by promoting repair of cell-cell interactions at the level of the brain microvascular endothelium. This review summarizes current knowledge in this area an...Continue Reading

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Citations

May 6, 2015·Peptides·Thomas P DavisRichard D Egleton
Jan 31, 2017·Nature Genetics·Helen R WarrenUNKNOWN UK Biobank CardioMetabolic Consortium BP working group
Apr 8, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Wazir AbdullahiPatrick T Ronaldson
Jan 11, 2018·Oxidative Medicine and Cellular Longevity·Giulia SitaFabiana Morroni
May 5, 2017·Journal of Central Nervous System Disease·Hrvoje BrzicaPatrick T Ronaldson
Jun 28, 2018·American Journal of Physiology. Cell Physiology·Wazir AbdullahiPatrick T Ronaldson
Sep 13, 2018·American Journal of Physiology. Cell Physiology·Ali E SifatThomas J Abbruscato
Jul 17, 2020·Frontiers in Neuroscience·Emely PimentelThangavel Samikkannu
May 20, 2020·Journal of Human Hypertension·Vasiliki KatsiDimitrios Tousoulis

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