Targeting Tumor-Associated Macrophages to Increase the Efficacy of Immune Checkpoint Inhibitors: A Glimpse into Novel Therapeutic Approaches for Metastatic Melanoma.

Cancers
Claudia CeciGrazia Graziani

Abstract

Immune checkpoint inhibitors (ICIs) represent a promising therapeutic intervention for a variety of advanced/metastatic solid tumors, including melanoma, but in a large number of cases, patients fail to establish a sustained anti-tumor immunity and to achieve a long-lasting clinical benefit. Cells of the tumor micro-environment such as tumor-associated M2 macrophages (M2-TAMs) have been reported to limit the efficacy of immunotherapy, promoting tumor immune evasion and progression. Thus, strategies targeting M2-TAMs have been suggested to synergize with immune checkpoint blockade. This review recapitulates the molecular mechanisms by which M2-TAMs promote cancer immune evasion, with focus on the potential cross-talk between pharmacological interventions targeting M2-TAMs and ICIs for melanoma treatment.

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Citations

Apr 4, 2021·Cancers·Meet PatelNeelu Puri
May 12, 2021·Experimental Hematology & Oncology·Linbang WangZhengxue Quan
May 18, 2021·Frontiers in Immunology·Kari A ShaverAlicja J Copik
Sep 4, 2021·Analytical Cellular Pathology (Amsterdam)·Sonja S MojsilovicJuan F Santibanez

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Methods Mentioned

BETA
RNA-seq
biopsies

Clinical Trials Mentioned

NCT01363206
NCT01134614
NCT02339571
NCT04382664
NCT02965716
NCT04330430
NCT03003676
NCT02807844
NCT02829723
NCT02718911

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