Targeting unfolded protein response in cancer and diabetes

Endocrine-related Cancer
Souren Mkrtchian

Abstract

The maturation of secretory and membrane proteins in the endoplasmic reticulum (ER) is tightly regulated by the unfolded protein response (UPR), a signal transduction pathway maintaining ER protein folding homeostasis. However, certain ER states are incompatible with cell survival and therefore the UPR may choose to eliminate severely disrupted cells by apoptosis. This is accomplished primarily through the activation of the transcription factor CCAAT-enhancer-binding protein homologous protein (CHOP). In the April 2015 issue of Endocrine-Related Cancer, researchers from the universities of South Carolina and Athens (Greece) suggested a novel mechanism of CHOP-mediated apoptosis connected with the suppression of a prominent cell cycle regulator with anti-apoptotic activity, p21. These findings and suggested clinical applications, such as potentiation of cancer chemotherapy and a novel therapeutic approach for type 2 diabetes, are discussed in the context of UPR.

References

Apr 23, 2008·Molecular and Cellular Biology·John-Paul UptonScott A Oakes
Oct 22, 2008·Oncogene·D N Dhanasekaran, E P Reddy
Jun 1, 2010·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Chrysovalantou MihailidouHippokratis Kiaris
Mar 27, 2012·Annual Review of Biochemistry·Sung Hoon Back, Randal J Kaufman
Sep 20, 2012·Biochemical Society Transactions·Mi-Kyung YoonRichard W Kriwacki
Oct 19, 2013·Cellular and Molecular Life Sciences : CMLS·Joseph W Brewer
Feb 12, 2015·Endocrine-related Cancer·Chrysovalantou MihailidouHippokratis Kiaris
Feb 12, 2015·Endocrine-related Cancer·Chrysovalantou MihailidouHippokratis Kiaris

❮ Previous
Next ❯

Citations

Oct 21, 2016·Pflügers Archiv : European journal of physiology·Chrysovalantou MihailidouHippokratis Kiaris
Dec 13, 2017·Frontiers in Immunology·Yuan YangBoxu Ren
Oct 21, 2017·Cancer Biotherapy & Radiopharmaceuticals·Buddhi Prakash Jain
May 1, 2021·Cancers·Bojana StefanovskaOlivia Fromigué

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis