Targeting VEGF/VEGFR to Modulate Antitumor Immunity

Frontiers in Immunology
Ju YangBaorui Liu

Abstract

In addition to the crucial role in promoting the growth of tumor vessels, vascular endothelial growth factor (VEGF) is also immunosuppressive. VEGF can inhibit the function of T cells, increase the recruitment of regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs), and hinder the differentiation and activation of dendritic cells (DCs). Recent studies have investigated the role of antiangiogenic agents in antitumor immunity, especially in recent 3 years. Therefore, it is necessary to update the role of targeting VEGF/VEGFR in antitumor immunity. In this review, we focus on the latest clinical and preclinical findings on the modulatory role of antiangiogenic agents targeting VEGF/VEGFR in immune cells, including effector T cells, Tregs, MDSCs, DCs, tumor-associated macrophages, and mast cells. Our review will be potentially helpful for the development of combinations of angiogenesis inhibitors with immunological modulators.

References

Nov 15, 1976·International Journal of Cancer. Journal International Du Cancer·D A KesslerJ Folkman
Apr 28, 2000·International Immunology·S C TrompA W Griffioen
Mar 7, 2001·Lancet·F Balkwill, A Mantovani
Jan 17, 2003·The New England Journal of Medicine·Lin ZhangGeorge Coukos
Dec 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yulia NefedovaDmitry Gabrilovich
Dec 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mikhail M DikovDavid P Carbone
Apr 6, 2005·Journal of Leukocyte Biology·Jonathan K H Tan, Helen C O'Neill
Apr 4, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anita E M DirkxArjan W Griffioen
Nov 24, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Betty LiKarin Jooss
Jan 24, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Caroline BouzinOlivier Feron
May 4, 2007·The Journal of Clinical Investigation·Tyler J Curiel
Jan 15, 2008·Cancer Immunology, Immunotherapy : CII·Takuya OsadaMichael A Morse
May 24, 2008·Nature Reviews. Cancer·Christie J AvraamidesJudith A Varner
Sep 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hester van CruijsenTanja D de Gruijl
Oct 18, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·James H FinkeRonald Bukowski
Nov 18, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dana D Hu-LoweSteve L Bender
Mar 12, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jennifer S KoJames H Finke
May 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susanna MandruzzatoPaola Zanovello
Nov 11, 2009·European Journal of Immunology·Hiroyuki SuzukiMitsuo Katano
Dec 17, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Aninda BasuDavid M Briscoe
Aug 4, 2010·Current Topics in Microbiology and Immunology·Lana E KandalaftGeorge Coukos
Mar 30, 2011·International Journal of Cancer. Journal International Du Cancer·Apostolos C ZiogasAristotle Bamias
Jul 16, 2011·Annual Review of Cell and Developmental Biology·Alicia S Chung, Napoleone Ferrara
Oct 19, 2011·Journal of Translational Medicine·Thea L Rogers, Ingunn Holen

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Citations

Jan 19, 2019·Journal of Personalized Medicine·David J Hermel, Darren Sigal
Mar 22, 2019·The Cancer Journal·Vidula V SukhatmeVikas P Sukhatme
May 12, 2019·International Journal of Molecular Sciences·Marilina García-Aranda, Maximino Redondo
Jul 30, 2019·Immunological Reviews·David AkhavanChristine E Brown
Jul 4, 2019·EMBO Molecular Medicine·Iris UribesalgoJosef M Penninger
Oct 20, 2019·Medicina·Vito LongoAntonella Argentiero
Dec 10, 2019·The Journal of Cell Biology·Kim Bich Nguyen, Stefani Spranger
Feb 29, 2020·Journal of Leukocyte Biology·Federica MaioneAnnalisa Chiocchetti
Jul 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ahmed El-Sharkawy, Ahmed Malki
Aug 21, 2020·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Hanan H Abd-ElhafeezSoha A Soliman
Aug 29, 2020·Future Oncology·Maryam SoleimaniChristian Kollmannsberger
May 7, 2020·Journal of Leukocyte Biology·Olga LeplinaElena Chernykh
Feb 8, 2020·Anti-cancer Agents in Medicinal Chemistry·Shi Zhou, Haijun Zhang
Jul 13, 2020·Experimental Dermatology·Andrea Luengas-MartinezHelen S Young
Oct 14, 2018·World Journal of Surgical Oncology·Li ZhuDihong Tang
Nov 7, 2019·Cellular and Molecular Life Sciences : CMLS·Roberta LuganoAnna Dimberg
Feb 11, 2020·Frontiers in Oncology·Bella S GuerrouahenEmmanuel T Akporiaye
Jun 6, 2020·Frontiers in Immunology·Joseph G SkeateW Martin Kast
Aug 1, 2020·Nature Reviews. Nephrology·C Marcela Díaz-MonteroJames H Finke
Jun 13, 2020·Frontiers in Immunology·Michal A RahatVijaya Iragavarapu-Charyulu
Sep 4, 2020·International Journal of Molecular Sciences·Michela Guardascione, Giuseppe Toffoli
Jun 20, 2020·Expert Opinion on Pharmacotherapy·Nilanchali SinghPrafull Ghatage
Jun 21, 2019·International Journal of Molecular Sciences·Loredana AlboniciRoberto Bei
Mar 10, 2020·Reviews in Endocrine & Metabolic Disorders·Pia BurmanAnn McCormack
Dec 7, 2019·Nature Reviews. Cancer·John H SampsonDavid M Ashley
Apr 2, 2020·Radiation Oncology Journal·Changhee KangEun Kyung Choi
Apr 5, 2020·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Daniel R AlmquistTanios S Bekaii-Saab
May 1, 2020·Frontiers in Pharmacology·Zhihong LiuLiwei Xie
May 17, 2019·Expert Opinion on Emerging Drugs·Umberto Malapelle, Antonio Rossi
Mar 17, 2019·International Journal of Molecular Sciences·Malcolm LimJodi M Saunus

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Datasets Mentioned

BETA
GM-CSF

Methods Mentioned

BETA
transgenic
biopsies
xenografts
xenograft

Clinical Trials Mentioned

NCT01339039

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