PMID: 26324041Sep 2, 2015Paper

Targeting Virus-host Interactions of HIV Replication

Current Topics in Medicinal Chemistry
Caroline WeydertZeger Debyser

Abstract

Cellular proteins that are hijacked by HIV in order to complete its replication cycle, form attractive new targets for antiretroviral therapy. In particular, the protein-protein interactions between these cellular proteins (cofactors) and viral proteins are of great interest to develop new therapies. Research efforts have led to the validation of different cofactors and some successes in therapeutic applications. Maraviroc, the first cofactor inhibitor approved for human medicinal use, provided a proof of concept. Furthermore, compounds developed as Integrase-LEDGF/p75 interaction inhibitors (LEDGINs) have advanced to early clinical trials. Other compounds targeting cofactors and cofactor-viral protein interactions are currently under development. Likewise, interactions between cellular restriction factors and their counteracting HIV protein might serve as interesting targets in order to impair HIV replication. In this respect, compounds targeting the Vif-APOBEC3G interaction have been described. In this review, we focus on compounds targeting the Integrase- LEDGF/p75 interaction, the Tat-P-TEFb interaction and the Vif-APOBEC3G interaction. Additionally we give an overview of currently discovered compounds presumably targeting ...Continue Reading

Citations

Apr 28, 2017·The Biochemical Journal·Anna GarbelliGiovanni Maga
Dec 7, 2017·International Reviews of Immunology·Faezeh BorzooeeMani Larijani
Jul 24, 2018·Current Drug Discovery Technologies·Debarshi K MahapatraShovanlal Gayen
Sep 29, 2017·Expert Opinion on Investigational Drugs·Yingshan HanMark A Wainberg
Jul 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Olga TarasovaVladimir Poroikov
Jan 12, 2017·International Journal of Molecular Sciences·María Eugenia González
May 12, 2019·Proceedings of the National Academy of Sciences of the United States of America·Usama AshrafNadia Naffakh
Aug 14, 2020·Journal of Chemical Information and Modeling·Natesh SinghBruno O Villoutreix
Dec 17, 2015·Future Medicinal Chemistry·Frauke Christ, Zeger Debyser

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