Targeting voltage sensors in sodium channels with spider toxins.

Trends in Pharmacological Sciences
Frank Bosmans, Kenton J Swartz

Abstract

Voltage-activated sodium (Nav) channels are essential in generating and propagating nerve impulses, placing them amongst the most widely targeted ion channels by toxins from venomous organisms. An increasing number of spider toxins have been shown to interfere with the voltage-driven activation process of mammalian Nav channels, possibly by interacting with one or more of their voltage sensors. This review focuses on our existing knowledge of the mechanism by which spider toxins affect Nav channel gating and the possible applications of these toxins in the drug discovery process.

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Citations

Jul 3, 2013·Proceedings of the National Academy of Sciences of the United States of America·Ken McCormackNeil A Castle
Jun 11, 2011·The Journal of Biological Chemistry·Yucheng XiaoTheodore R Cummins
Aug 31, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jinti WangWilliam A Catterall
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