Targeting von Willebrand Factor in Ischaemic Stroke: Focus on Clinical Evidence

Thrombosis and Haemostasis
Nina BuchteleB Jilma

Abstract

Despite great efforts in stroke research, disability and recurrence rates in ischaemic stroke remain unacceptably high. To address this issue, one potential target for novel therapeutics is the glycoprotein von Willebrand factor (vWF), which increases in thrombogenicity especially under high shear rates as it bridges between vascular sub-endothelial collagen and platelets. The rationale for vWF as a potential target in stroke comes from four bodies of evidence. (1) Animal models which recapitulate the pathogenesis of stroke and validate the concept of targeting vWF for stroke prevention and the use of the vWF cleavage enzyme ADAMTS13 in acute stroke treatment. (2) Extensive epidemiologic data establishing the prognostic role of vWF in the clinical setting showing that high vWF levels are associated with an increased risk of first stroke, stroke recurrence or stroke-associated mortality. As such, vWF levels may be a suitable marker for further risk stratification to potentially fine-tune current risk prediction models which are mainly based on clinical and imaging data. (3) Genetic studies showing an association between vWF levels and stroke risk on genomic levels. Finally, (4) studies of patients with primary disorders of exces...Continue Reading

Citations

Nov 7, 2019·Journal of Neurointerventional Surgery·Andrew DouglasKaren Doyle
Oct 26, 2018·Stroke; a Journal of Cerebral Circulation·Titilope A FasipeSean P Marrelli
Feb 6, 2020·Journal of Thrombosis and Haemostasis : JTH·Shuhao ZhuBernd Jilma
Apr 11, 2020·Journal of Thrombosis and Haemostasis : JTH·Shuhao ZhuBernd Jilma
Jun 15, 2021·Frontiers in Neurology·Saiyet de la C BaezPedro Valdes-Sosa

❮ Previous
Next ❯

Methods Mentioned

BETA
pharmacotherapy
imaging techniques

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.